Multiwalled carbon nanotubes induced hypotension by regulating the central nervous system
文献类型：期刊论文
| 作者 | Ma, Xiaowei1,2; Zhong, Lin1,2; Guo, Hongbo1,2; Wang, Yifeng1,2; Gong, Ningqiang1,2; Wang, Yuqing1,2; Cai, Jun3; Liang, Xing-Jie1,2 |
| 刊名 | Advanced functional materials
 |
| 出版日期 | 2018-03-14 |
| 卷号 | 28期号:11页码:9 |
| ISSN号 | 1616-301X |
| 关键词 | Hypotension Multiwalled carbon nanotubes Nitric oxide Sympathetic nerve |
| DOI | 10.1002/adfm.201705479 |
| 通讯作者 | Zhong, lin(zhonglin0817@hotmail.com) ; Liang, xing-jie(liangxj@nanoctr.cn) |
| 英文摘要 | Cardiovascular disease is the leading cause of death worldwide. normal blood pressure is very important for overall well-being and unexpected decrease in blood pressure may cause many detrimental consequences. the attractive properties of multiwalled carbon nanotubes (mwcnts) entice their usage in many cutting edge brain-specific therapies. however, the effects of mwcnts to the central nervous system are not fully understood. in this work, the authors report that carbon nanotubes can significantly cause blood pressure to fall down when introduced into the brain at very low dosage. it is found that mwcnts induce increased expression of neuronal nitric oxide synthase in the medulla cardiovascular center, which consequently attenuate sympathetic nerve activity and cause decrease in blood pressure and heart rate. in addition, mwcnts promote acetylation and nuclear translocation of nuclear factor-b in brain cells. this work illustrates how cnts can potentially change blood pressure by interrupting the central nervous system and is significant to the biomedical applications of cnts. |
| WOS关键词 | NITRIC-OXIDE SYNTHASE ; ROSTRAL VENTROLATERAL MEDULLA ; C-FOS EXPRESSION ; BLOOD-PRESSURE ; KAPPA-B ; CARDIOVASCULAR-SYSTEM ; BRAIN-STEM ; ENDOTHELIAL DYSFUNCTION ; SENSORY STIMULATION ; SPINAL-CORD |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000427110100008 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178081 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zhong, Lin; Liang, Xing-Jie |
| 作者单位 | 1.Chinese Acad Sci, Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Fuwai Cardiovasc Hosp, Hypertens Ctr, Beijing 100037, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Xiaowei,Zhong, Lin,Guo, Hongbo,et al. Multiwalled carbon nanotubes induced hypotension by regulating the central nervous system[J]. Advanced functional materials,2018,28(11):9. |
| APA | Ma, Xiaowei.,Zhong, Lin.,Guo, Hongbo.,Wang, Yifeng.,Gong, Ningqiang.,...&Liang, Xing-Jie.(2018).Multiwalled carbon nanotubes induced hypotension by regulating the central nervous system.Advanced functional materials,28(11),9. |
| MLA | Ma, Xiaowei,et al."Multiwalled carbon nanotubes induced hypotension by regulating the central nervous system".Advanced functional materials 28.11(2018):9. |
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来源：高能物理研究所
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