Dual effect of peg-pe micelle over the oligomerization and fibrillation of human islet amyloid polypeptide
文献类型：期刊论文
| 作者 | Fang, Xiaocui1; Yousaf, Maryam1,2; Huang, Qunxing1; Yang, Yanlian1; Wang, Chen1 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2018-03-13 |
| 卷号 | 8页码:12 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-018-22820-w |
| 通讯作者 | Yang, yanlian(yangyl@nanoctr.cn) ; Wang, chen(wangch@nanoctr.cn) |
| 英文摘要 | The oligomerization and fibrillation of human islet amyloid polypeptide (hiapp) play a central role in the pathogenesis of type 2 diabetes. strategies for remodelling the formation of hiapp oligomers and fibrils have promising application potential in type 2 diabetes therapy. herein, we demonstrated that peg-pe micelle could inhibit hiapp oligomerization and fibrillation through blocking the hydrophobic interaction and the conformational change from random coil to beta-sheet structures of hiapp. in addition, we also found that peg-pe micelle could remodel the preformed hiapp fibrils allowing the formation of short fibrils and co-aggregates. taken together, peg-pe micelle could rescue hiapp-induced cytotoxicity by decreasing the content of hiapp oligomers and fibrils that are related to the oxidative stress and cell membrane permeability. this study could be beneficial for the design and development of antiamyloidogenic agents. |
| WOS关键词 | PROTEIN MISFOLDING DISEASES ; DIABETES-MELLITUS ; TRANSGENIC MICE ; IN-VITRO ; ALZHEIMERS-DISEASE ; AMYLIN ; AGGREGATION ; INHIBITION ; TOXICITY ; FIBRILLOGENESIS |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000427243300014 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178083 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Yang, Yanlian; Wang, Chen |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China 2.Univ Agr Faisalabad, Dept Chem, Radiat Chem Lab, Faisalabad 38000, Pakistan |
| 推荐引用方式 GB/T 7714 | Fang, Xiaocui,Yousaf, Maryam,Huang, Qunxing,et al. Dual effect of peg-pe micelle over the oligomerization and fibrillation of human islet amyloid polypeptide[J]. Scientific reports,2018,8:12. |
| APA | Fang, Xiaocui,Yousaf, Maryam,Huang, Qunxing,Yang, Yanlian,&Wang, Chen.(2018).Dual effect of peg-pe micelle over the oligomerization and fibrillation of human islet amyloid polypeptide.Scientific reports,8,12. |
| MLA | Fang, Xiaocui,et al."Dual effect of peg-pe micelle over the oligomerization and fibrillation of human islet amyloid polypeptide".Scientific reports 8(2018):12. |
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来源：高能物理研究所
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