Injectable hexapeptide hydrogel for localized chemotherapy prevents breast cancer recurrence
文献类型：期刊论文
| 作者 | Qi, Yingqiu1,2,3; Min, Huan1,3; Mujeeb, Ayeesha3; Zhang, Yinlong3; Han, Xuexiang3; Zhao, Xiao3; Anderson, Greg J.4; Zhao, Ying3,5; Nie, Guangjun3,5 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2018-02-28 |
| 卷号 | 10期号:8页码:6972-6981 |
| ISSN号 | 1944-8244 |
| 关键词 | Peptide self-assembly Hydrogel Injectable Localized chemotherapy Cancer recurrence |
| DOI | 10.1021/acsami.7b19258 |
| 通讯作者 | Zhao, ying(zhaoying@nanoctr.cn) ; Nie, guangjun(niegj@nanoctr.cn) |
| 英文摘要 | Although postsurgical chemotherapy is frequently used for the treatment of breast cancer, tumor recurrence is still a frequent event. enhancing the efficacy of chemotherapy via localized drug delivery may help to prevent breast cancer recurrence. to achieve this goal, we designed a hydrogel nanocarrier that could be injected at the tumor site by coassembly of tailor-made hexapeptide and doxorubicin. evidently, on the basis of our findings, the sustained release of drug from the hydrogel led to a reduction in cancer recurrence, including the suppression of primary regrowth and distant metastasis. this localized chemotherapy strategy did not show any obvious side effects in vivo and represents a promising adjuvant therapeutic strategy for breast cancer recurrence. |
| WOS关键词 | CONTROLLED-RELEASE ; DRUG-DELIVERY ; SUPRAMOLECULAR HYDROGELS ; THERMOSENSITIVE HYDROGEL ; THERAPEUTIC APPLICATION ; NANOFIBER HYDROGELS ; PEPTIDE ; DOXORUBICIN ; STATISTICS ; METASTASIS |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000426618000022 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178096 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zhao, Ying; Nie, Guangjun |
| 作者单位 | 1.Northeastern Univ, Coll Sci, Shenyang 110819, Liaoning, Peoples R China 2.Northeastern Univ, Coll Life & Hlth Sci, Shenyang 110819, Liaoning, Peoples R China 3.CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 4.Royal Brisbane Hosp, QIMR Berghofer Med Res Inst, Brisbane, Qld 4029, Australia 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qi, Yingqiu,Min, Huan,Mujeeb, Ayeesha,et al. Injectable hexapeptide hydrogel for localized chemotherapy prevents breast cancer recurrence[J]. Acs applied materials & interfaces,2018,10(8):6972-6981. |
| APA | Qi, Yingqiu.,Min, Huan.,Mujeeb, Ayeesha.,Zhang, Yinlong.,Han, Xuexiang.,...&Nie, Guangjun.(2018).Injectable hexapeptide hydrogel for localized chemotherapy prevents breast cancer recurrence.Acs applied materials & interfaces,10(8),6972-6981. |
| MLA | Qi, Yingqiu,et al."Injectable hexapeptide hydrogel for localized chemotherapy prevents breast cancer recurrence".Acs applied materials & interfaces 10.8(2018):6972-6981. |
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来源：高能物理研究所
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