Ph-triggered peptide self-assembly for targeting imaging and therapy toward angiogenesis with enhanced signals
文献类型：期刊论文
| 作者 | Qian, Yixia1,2; Wang, Weizhi1; Wang, Zihua1; Jia, Xiangqian1; Han, Qiuju1; Rostami, Iman1; Wang, Yuehua1; Hu, Zhiyuan1,3,4 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2018-03-07 |
| 卷号 | 10期号:9页码:7871-7881 |
| 关键词 | Ph-triggered Vegfr2 Self-assembly Biaimaging Cancer therapy |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.8b00583 |
| 通讯作者 | Wang, weizhi(wangwz@nanoctr.cn) ; Hu, zhiyuan(huzy@nanoctr.cn) |
| 英文摘要 | Mild acidic environment and angiogenesis are two typical characteristics of tumor. the specific response toward both lower ph and angiogenesis may enhance the targeting ability both for drug and diagnostic probe delivery. herein, we present a kind of dual responding self-assembled nanotransformation material that is tumor angiogenesis targeting and ph triggered based on amphiphilic conjugation between peptides (stp) and aromatic molecules (tetraphenyl-ethylene (tpe)). the morphology of the self-assembled peptide conjugates is responsibly changed from nanoparticles in neutral condition to nanofibers in acidic condition, which "turn on" the in vivo targeting imaging and accelerate the efficient drug delivery and in vivo therapy. on the basis of the well-controlled nanotransformation both in vitro and in vivo, we envisioned the successful demonstration of the responding materials would open a new avenue in turn on targeting imaging diagnostics and specific cancer therapeutics. |
| WOS关键词 | ANTICANCER DRUG-DELIVERY ; TUMOR MICROENVIRONMENT ; CANCER-THERAPY ; CELLS ; NANOPARTICLES ; FABRICATION ; BIOMATERIALS ; RECEPTORS ; MICELLES ; BIOLOGY |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000427204100037 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178098 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Wang, Weizhi; Hu, Zhiyuan |
| 作者单位 | 1.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Sinodanish Coll, Beijing 100049, Peoples R China 4.Fujian Med Univ, Sch Basic Med Sci, Ctr Neurosci Res, Fuzhou 350108, Fujian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qian, Yixia,Wang, Weizhi,Wang, Zihua,et al. Ph-triggered peptide self-assembly for targeting imaging and therapy toward angiogenesis with enhanced signals[J]. Acs applied materials & interfaces,2018,10(9):7871-7881. |
| APA | Qian, Yixia.,Wang, Weizhi.,Wang, Zihua.,Jia, Xiangqian.,Han, Qiuju.,...&Hu, Zhiyuan.(2018).Ph-triggered peptide self-assembly for targeting imaging and therapy toward angiogenesis with enhanced signals.Acs applied materials & interfaces,10(9),7871-7881. |
| MLA | Qian, Yixia,et al."Ph-triggered peptide self-assembly for targeting imaging and therapy toward angiogenesis with enhanced signals".Acs applied materials & interfaces 10.9(2018):7871-7881. |
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来源：高能物理研究所
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