Mitochondrial ferritin is a hypoxia-inducible factor 1 alpha-inducible gene that protects from hypoxia-induced cell death in brain
文献类型：期刊论文
| 作者 | Wu, Qiong1,2,3,4; Wu, Wen-Shuang1,3,4; Su, Lin1; Zheng, Xin1; Wu, Wen-Yue1; Santambrogio, Paolo2; Gou, Yu-Jing1; Hao, Qian1; Wang, Pei-Na1; Li, Ya-Ru1 |
| 刊名 | Antioxidants & redox signaling
 |
| 出版日期 | 2018-03-22 |
| 页码 | 15 |
| ISSN号 | 1523-0864 |
| 关键词 | Mitochondrial ferritin Hif-1 alpha Hypoxia-induced apoptosis Ros |
| DOI | 10.1089/ars.2017.7063 |
| 通讯作者 | Levi, sonia(levi.sonia@hsr.it) ; Chang, yan-zhong(frankyzchang@yahoo.com.hk) |
| 英文摘要 | Aims: mitochondrial ferritin (protein [ftmt]) is preferentially expressed in cell types of high metabolic activity and oxygen consumption, which is consistent with its role of sequestering iron and preventing oxygen-derived redox damage. as of yet, the mechanisms of ftmt regulation and the protection ftmt affords remain largely unknown. results: here, we report that hypoxia-inducible factor 1 alpha (hif-1 alpha) can upregulate ftmt expression. we verify one functional hypoxia-response element (hre) in the positive regulatory region and two hres possessing hif-1 alpha binding activity in the minimal promoter region of the human ftmt gene. we also demonstrate that ftmt can alleviate hypoxia-induced brain cell death by sequestering uncommitted iron, whose levels increase with hypoxia in these cells. innovation: in the absence of ftmt, this catalytic metal excess catalyzes the production of cytotoxic reactive oxygen species. conclusion: thus, the cell ability to increase expression of ftmt during hypoxia may be a skill to avoid tissue damage derived from oxygen limitation. |
| WOS关键词 | TRANSCRIPTION FACTOR ; HYPOBARIC HYPOXIA ; OXIDATIVE DAMAGE ; IRON-METABOLISM ; FACTOR-I ; MACULAR DEGENERATION ; ERYTHROPOIETIN GENE ; INDUCED APOPTOSIS ; MOUSE-BRAIN ; HELA-CELLS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| WOS类目 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| 出版者 | MARY ANN LIEBERT, INC |
| WOS记录号 | WOS:000428040100001 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178106 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Levi, Sonia; Chang, Yan-Zhong |
| 作者单位 | 1.Hebei Normal Univ, Coll Life Sci, Key Lab Anim Physiol Biochem & Mol Biol Hebei Pro, Lab Mol Iron Metab, 20 Nanerhuan Eastern Rd, Shijiazhuang 050024, Hebei, Peoples R China 2.Ist Sci San Raffaele, Div Neurosci, Via Olgettina 58, I-20132 Milan, Italy 3.Hebei Univ Chinese Med, Coll Basic Med, Shijiazhuang, Hebei, Peoples R China 4.Hebei Med Univ, Hosp 3, Dept Clin Lab, Shijiazhuang, Hebei, Peoples R China 5.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China 6.Univ Vita Salute San Raffaele, Milan, Italy |
| 推荐引用方式 GB/T 7714 | Wu, Qiong,Wu, Wen-Shuang,Su, Lin,et al. Mitochondrial ferritin is a hypoxia-inducible factor 1 alpha-inducible gene that protects from hypoxia-induced cell death in brain[J]. Antioxidants & redox signaling,2018:15. |
| APA | Wu, Qiong.,Wu, Wen-Shuang.,Su, Lin.,Zheng, Xin.,Wu, Wen-Yue.,...&Chang, Yan-Zhong.(2018).Mitochondrial ferritin is a hypoxia-inducible factor 1 alpha-inducible gene that protects from hypoxia-induced cell death in brain.Antioxidants & redox signaling,15. |
| MLA | Wu, Qiong,et al."Mitochondrial ferritin is a hypoxia-inducible factor 1 alpha-inducible gene that protects from hypoxia-induced cell death in brain".Antioxidants & redox signaling (2018):15. |
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来源：高能物理研究所
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