Magnetic resonance imaging quantification and biodistribution of magnetic nanoparticles using &itt&it1-enhanced contrast
文献类型：期刊论文
| 作者 | Lv, Y. B.1; Chandrasekharan, P.2,3; Li, Y.4; Liu, X. L.5; Avila, J. P.2; Yang, Y.1; Chuang, K. H.2,3; Liang, Xing-Jie5; Ding, J.1 |
| 刊名 | Journal of materials chemistry b
 |
| 出版日期 | 2018-03-14 |
| 卷号 | 6期号:10页码:1470-1478 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c7tb03129g |
| 通讯作者 | Liu, x. l.(liuxiaoli@nanoctr.cn) ; Ding, j.(msedingj@nus.edu.sg) |
| 英文摘要 | Magnetic iron oxide nanoparticles have been used for various applications such as in the treatment of iron deficiency, as theranostic agents, and as drug carriers. the effective delivery of magnetic iron oxide nanoparticles into the lesion and iron quantification are vital for in vivo theranostic application. to determine the feasibility of using t-1 contrast to non-invasively quantify and monitor the ionps in vivo, monodispersed gd-doped iron oxide nanoparticles (gdionps) with 4 nm core size were fabricated and were used as t-1-weighted contrast agents to quantify iron contents based on mri longitudinal relaxation times (t-1). signal enhancement in positive t-1 contrast caused by gdionps was observed in this work. the in vivo t-1 relaxivity of gdionps in a tumor matched well with both in vitro t-1 relaxivity and icp-ms results, demonstrating that the concentration of iron at the tumor site can be directly read from real-time in vivo mri t-1 relaxivity. hence, by using this strategy, the fe content in the lesion can be accurately monitored based on mri longitudinal relaxation times, and this may shed light on effective magnetic hyperthermia cancer therapy in future. |
| WOS关键词 | IRON-OXIDE NANOPARTICLES ; IN-VIVO ; FLUID HYPERTHERMIA ; AGENTS ; DELIVERY ; MRI ; TUMOR ; CLEARANCE ; LIPOSOMES ; THERAPY |
| WOS研究方向 | Materials Science |
| WOS类目 | Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000429048600006 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178134 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Liu, X. L.; Ding, J. |
| 作者单位 | 1.Natl Univ Singapore, Fac Engn, Dept Mat Sci & Engn, 7 Engn Dr 1, Singapore 117574, Singapore 2.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Anat, 4 Med Dr,MD10, Singapore 117597, Singapore 3.Singapore Bioimaging Consortium A STAR, Lab Mol Imaging, 11 Biopolis Way,02-02 Helios, Singapore 138667, Singapore 4.Xiamen Univ, Key Lab Biomed Engn Fujian Prov Univ, Res Ctr Biomed Engn Xiamen, Dept Biomat,Coll Mat, Xiamen 310005, Peoples R China 5.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lv, Y. B.,Chandrasekharan, P.,Li, Y.,et al. Magnetic resonance imaging quantification and biodistribution of magnetic nanoparticles using &itt&it1-enhanced contrast[J]. Journal of materials chemistry b,2018,6(10):1470-1478. |
| APA | Lv, Y. B..,Chandrasekharan, P..,Li, Y..,Liu, X. L..,Avila, J. P..,...&Ding, J..(2018).Magnetic resonance imaging quantification and biodistribution of magnetic nanoparticles using &itt&it1-enhanced contrast.Journal of materials chemistry b,6(10),1470-1478. |
| MLA | Lv, Y. B.,et al."Magnetic resonance imaging quantification and biodistribution of magnetic nanoparticles using &itt&it1-enhanced contrast".Journal of materials chemistry b 6.10(2018):1470-1478. |
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