Ultrasensitive tyrosinase-activated turn-on near-infrared fluorescent probe with a rationally designed urea bond for selective imaging and photodamage to melanoma cells
文献类型：期刊论文
| 作者 | Li, Zhipeng1,2; Wang, Yi-Feng3,4; Zeng, Chengchu1,2; Hu, Liming1,2; Liang, Xing-Jie3,4 |
| 刊名 | Analytical chemistry
 |
| 出版日期 | 2018-03-20 |
| 卷号 | 90期号:6页码:3666-3669 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/acs.analchem.7b05369 |
| 通讯作者 | Hu, liming(huliming@bjut.edu.cn) ; Liang, xing-jie(liangxj@nanoctr.cn) |
| 英文摘要 | Melanoma is a highly aggressive malignancy and early monitoring and diagnosis are challenging at present. tyrosinase is overexpressed in melanoma and regarded as an important biological marker for diagnosis and treatment. thus, the selective and sensitive detection of tyrosinase is of great significance. to date, a few fluorescent probes have been reported for the detection of tyrosinase in vitro or in vivo. however, a highly sensitive near-infrared probe for tyrosinase monitoring is still missing. in this study, the gibbs free energy change of different urea bonds during spontaneous hydrolysis is analyzed with the aid of chemical thermodynamic computation. on the basis of this analysis, we modified the dye methylene blue with a rationally designed urea bond to specifically create a probe, called mb1, for rapid detection of tyrosinase. our experimental results demonstrated that mb1 can serve as a highly sensitive near-infrared responsive fluorescent probe for the monitoring and bioimaging of tyrosinase. in addition, the activated mb1 probe can effectively kill melanoma cells by photodynamic therapy. thus, the near-infrared probe has great potential for monitoring and treating melanoma. |
| WOS关键词 | MALIGNANT-MELANOMA ; THERAPY |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Analytical |
| 语种 | 英语 |
| WOS记录号 | WOS:000428219600005 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178142 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Hu, Liming; Liang, Xing-Jie |
| 作者单位 | 1.Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China 2.Beijing Key Lab Environm & Oncol, Beijing 100124, Peoples R China 3.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 First North Rd, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhipeng,Wang, Yi-Feng,Zeng, Chengchu,et al. Ultrasensitive tyrosinase-activated turn-on near-infrared fluorescent probe with a rationally designed urea bond for selective imaging and photodamage to melanoma cells[J]. Analytical chemistry,2018,90(6):3666-3669. |
| APA | Li, Zhipeng,Wang, Yi-Feng,Zeng, Chengchu,Hu, Liming,&Liang, Xing-Jie.(2018).Ultrasensitive tyrosinase-activated turn-on near-infrared fluorescent probe with a rationally designed urea bond for selective imaging and photodamage to melanoma cells.Analytical chemistry,90(6),3666-3669. |
| MLA | Li, Zhipeng,et al."Ultrasensitive tyrosinase-activated turn-on near-infrared fluorescent probe with a rationally designed urea bond for selective imaging and photodamage to melanoma cells".Analytical chemistry 90.6(2018):3666-3669. |
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