Functionalized gold nanoclusters identify highly reactive oxygen species in living organisms
文献类型：期刊论文
| 作者 | Xie, Yangzhouyun1,2,3; Xianyu, Yunlei1,2; Wang, Nuoxin1,2; Yan, Zhaoyang4; Liu, Yong1,2; Zhu, Kui4; Hatzakis, Nikos S.5; Jiang, Xingyu1,2,3 |
| 刊名 | Advanced functional materials
 |
| 出版日期 | 2018-04-05 |
| 卷号 | 28期号:14页码:7 |
| 关键词 | Fluorescent imaging Gold nanoclusters Intracellular detection Reactive oxygen species |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201702026 |
| 通讯作者 | Jiang, xingyu(xingyujiang@nanoctr.cn) |
| 英文摘要 | Surface engineering of nanomaterials allows fine tuning of their interactions with biological systems, and thus can benefit their applications in monitoring intracellular events. herein, the facile synthesis of ligand-functionalized gold nanoclusters (auncs) as intracellular probes targeting highly reactive oxygen species (hros, such as center dot oh, clo-, and onoo-) is demonstrated. selected ligands such as quaternary ammonium and oligopeptides are utilized to modulate the surface chemistry of auncs. it is shown that auncs decorated with the cell-penetrating oligoarginine peptide facilitate cellular uptake and intracellular imaging of hros in living cells and the zebrafish, with high stability and selectivity. |
| WOS关键词 | METAL NANOCLUSTERS ; FLUORESCENT-PROBES ; LIVE CELLS ; HYDROGEN-PEROXIDE ; OPTICAL PROBE ; NANOPARTICLES ; IDENTIFICATION ; PEROXYNITRITE ; EMISSION ; RADICALS |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000429410400032 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178144 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Jiang, Xingyu |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Sino Danish Ctr Educ & Res, Beijing 100190, Peoples R China 4.China Agr Univ, Beijing 100193, Peoples R China 5.Univ Copenhagen, Dept Chem, DK-2100 Copenhagen, Denmark |
| 推荐引用方式 GB/T 7714 | Xie, Yangzhouyun,Xianyu, Yunlei,Wang, Nuoxin,et al. Functionalized gold nanoclusters identify highly reactive oxygen species in living organisms[J]. Advanced functional materials,2018,28(14):7. |
| APA | Xie, Yangzhouyun.,Xianyu, Yunlei.,Wang, Nuoxin.,Yan, Zhaoyang.,Liu, Yong.,...&Jiang, Xingyu.(2018).Functionalized gold nanoclusters identify highly reactive oxygen species in living organisms.Advanced functional materials,28(14),7. |
| MLA | Xie, Yangzhouyun,et al."Functionalized gold nanoclusters identify highly reactive oxygen species in living organisms".Advanced functional materials 28.14(2018):7. |
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来源：高能物理研究所
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