Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and fxa
文献类型：期刊论文
| 作者 | Xia, Shibo1,2; Li, Juan1; Zu, Mian1; Li, Jinxia1; Liu, Jinke1; Bai, Xue1,2; Chang, Yanan1; Chen, Kui1,2; Gu, Weihong1,2; Zeng, Li3 |
| 刊名 | Nanomedicine-nanotechnology biology and medicine
 |
| 出版日期 | 2018-04-01 |
| 卷号 | 14期号:3页码:929-939 |
| 关键词 | Fullerenols Anticoagulation Thrombin Fxa Ca2+ Inhibition of thrombosis |
| ISSN号 | 1549-9634 |
| DOI | 10.1016/j.nano.2017.12.013 |
| 通讯作者 | Zhao, lina(linazhao@ihep.ac.cn) ; Xing, gengyan(xgy1350138@163.com) ; Xing, gengmei(xinggm@ihep.ac.cn) |
| 英文摘要 | Thrombus is one of main causes of death in the world and also a vital trouble of biomaterials application in vivo. recently, effect of fullerenol nanomaterials on anticoagulation was found in our research through extension of bleeding times in treated sprague-dawley rats via intravenous injection. inhibiting of fullerenols on thrombosis was ascertained further by thromboembolism model. effects of fullerenols on intrinsic and extrinsic pathway were distinct in prolonging activated partial thromboplastin time and prothrombin time, which supported that fullerenols induced defects in both pathways. inhibited activities of activated coagulation factor x (fxa) and thrombin were verified by experiments in vitro and autodock vina. the results suggest that fullerenols depending on small size and certainly surface property occupied the active domain of fxa and thrombin to block their activity; further, thrombosis was inhibited. this putative mechanism offers an insight into how fullerenol nps were utilized further in biomedical applications. (c) 2018 elsevier inc. all rights reserved. |
| WOS关键词 | PLATELET-AGGREGATION ; ANTITHROMBOTIC ACTIVITIES ; PROCOAGULANT ACTIVITY ; STEM-CELLS ; IN-VITRO ; FIBRINOGEN ; ANTICOAGULANT ; BINDING ; PERMEABILITY ; SUPPRESSION |
| WOS研究方向 | Science & Technology - Other Topics ; Research & Experimental Medicine |
| WOS类目 | Nanoscience & Nanotechnology ; Medicine, Research & Experimental |
| 语种 | 英语 |
| WOS记录号 | WOS:000429528900027 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178169 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zhao, Lina; Xing, Gengyan; Xing, Gengmei |
| 作者单位 | 1.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China 2.UCAS, Beijing, Peoples R China 3.Gen Hosp Chinese Peoples Armed Police Forces, Dept Orthoped, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia, Shibo,Li, Juan,Zu, Mian,et al. Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and fxa[J]. Nanomedicine-nanotechnology biology and medicine,2018,14(3):929-939. |
| APA | Xia, Shibo.,Li, Juan.,Zu, Mian.,Li, Jinxia.,Liu, Jinke.,...&Xing, Gengmei.(2018).Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and fxa.Nanomedicine-nanotechnology biology and medicine,14(3),929-939. |
| MLA | Xia, Shibo,et al."Small size fullerenol nanoparticles inhibit thrombosis and blood coagulation through inhibiting activities of thrombin and fxa".Nanomedicine-nanotechnology biology and medicine 14.3(2018):929-939. |
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