Probing adsorption behaviors of bsa onto chiral surfaces of nanoparticles
文献类型：期刊论文
| 作者 | Wang, Xinyi1,2,3,4; Wang, Xiaofeng5; Wang, Mingzhe1,2; Zhang, Di4; Yang, Qi4; Liu, Tao1,2; Lei, Rong6; Zhu, Shuifang6; Zhao, Yuliang1,2; Chen, Chunying1,2 |
| 刊名 | Small
 |
| 出版日期 | 2018-04-19 |
| 卷号 | 14期号:16页码:10 |
| 关键词 | Chiral surfaces Molecular dynamic simulation Nanoparticles Protein adsorption behavior |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201703982 |
| 通讯作者 | Chen, chunying(chenchy@nanoctr.cn) |
| 英文摘要 | Chiral properties of nanoscale materials are of importance as they dominate interactions with proteins in physiological environments; however, they have rarely been investigated. in this study, a systematic investigation is conducted for the adsorption behaviors of bovine serum albumin (bsa) onto the chiral surfaces of gold nanoparticles (aunps), involving multiple techniques and molecular dynamic (md) simulation. the adsorption of bsa onto both l-and d-chiral surfaces of aunps shows discernible differences involving thermodynamics, adsorption orientation, exposed charges, and affinity. as a powerful supplement, md simulation provides a molecular-level understanding of protein adsorption onto nanochiral surfaces. salt bridge interaction is proposed as a major driving force at protein-nanochiral interface interaction. the spatial distribution features of functional groups (-coo-, -nh3+, and -ch3) of chiral molecules on the nanosurface play a key role in the formation and location of salt bridges, which determine the bsa adsorption orientation and binding strength to chiral surfaces. sequentially, bsa corona coated on nanochiral surfaces affects their uptake by cells. the results enhance the understanding of protein corona, which are important for biological effects of nanochirality in living organisms. |
| WOS关键词 | GOLD NANOPARTICLES ; PROTEIN CORONA ; CELL-ADHESION ; PLASMONIC NANOSTRUCTURES ; CARBON NANOTUBES ; BLOOD PROTEINS ; ALBUMIN ; SYSTEMS ; SIZE ; CYTOTOXICITY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000430398600010 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178170 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Chen, Chunying |
| 作者单位 | 1.Univ Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China 3.Liaoning Univ, Coll Environm, Shenyang 110036, Liaoning, Peoples R China 4.Shenyang Agr Univ, Coll Sci, Shenyang 110866, Liaoning, Peoples R China 5.Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China 6.Chinese Acad Inspect & Quarantine, Inst Plant Quarantine, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xinyi,Wang, Xiaofeng,Wang, Mingzhe,et al. Probing adsorption behaviors of bsa onto chiral surfaces of nanoparticles[J]. Small,2018,14(16):10. |
| APA | Wang, Xinyi.,Wang, Xiaofeng.,Wang, Mingzhe.,Zhang, Di.,Yang, Qi.,...&Chen, Chunying.(2018).Probing adsorption behaviors of bsa onto chiral surfaces of nanoparticles.Small,14(16),10. |
| MLA | Wang, Xinyi,et al."Probing adsorption behaviors of bsa onto chiral surfaces of nanoparticles".Small 14.16(2018):10. |
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来源：高能物理研究所
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