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Light-triggered retention and cascaded therapy of albumin-based theranostic nanomedicines to alleviate tumor adaptive treatment tolerance

文献类型：期刊论文

作者Chen, Jing1; Liu, Lu2; Motevalli, Seyed Mohammad2; Wu, Xiaoli1; Yang, Xiao-Hong3; Li, Xianlei2; Han, Lu3; Magrini, Andrea4; Guo, Weisheng2; Chang, Jin1
刊名Advanced functional materials
出版日期2018-04-25
卷号28期号:17页码:10
关键词Cascaded synergistic therapy Hypoxia Light-triggered aggregation Nanomedicine Photodynamic therapy
ISSN号1616-301X
DOI10.1002/adfm.201707291
通讯作者Guo, weisheng(tjuguoweisheng@126.com) ; Chang, jin(jingchang@tju.edu.cn) ; Liang, xing-jie(liangxj@nanoctr.cn)
英文摘要Tumor adaptive treatment tolerance associated with chemotherapy originates from low tumor accumulation and adverse effects and remains a formidable challenge for cancer therapy. herein, human serum albumin (hsa)-based nanomedicines modified with diazirine and loaded with indocyanine green (icg) and tirapazamine (tpz), denoted as icg/tpz@hsa dnms are developed. the obtained icg/tpz@hsa dnms can efficiently eradicate the tumors through a cascade of synergistic events triggered by the sequential irradiation of lasers in the tumor area. upon a 405 nm laser irradiation, the icg/tpz@hsa dnms are able to form aggregates via crosslinking and thus realized enhanced tumor site accumulation and prolonged retention time. the following irradiation at tumor area with an 808 nm laser-generated local hyperthermia and reactive oxygen species, which results in efficient tumor ablation and increased local hypoxia in the tumor microenvironment. the resulted local hypoxia further activates the initially nontoxic tpz to a highly cytotoxic derivative, by which precisely bioactivated chemotherapy is achieved following the phototherapy. thus, upon the laser irradiations, a cascade of aggregation, phototherapy, and bioactivated chemotherapy is successfully triggered, which achieves efficient precise eradication of tumors without detectable side effects in vivo.
WOS关键词PHOTODYNAMIC THERAPY ; DRUG-DELIVERY ; ENHANCED PERMEABILITY ; NANOPARTICLE DELIVERY ; GOLD NANOPARTICLES ; QUANTUM DOTS ; HYPOXIA ; CANCER ; RADIOTHERAPY ; PHOTOTHERAPY
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
语种英语
WOS记录号WOS:000430658300025
出版者WILEY-V C H VERLAG GMBH
URI标识http://www.irgrid.ac.cn/handle/1471x/2178175
专题高能物理研究所
通讯作者Guo, Weisheng; Chang, Jin; Liang, Xing-Jie
作者单位1.Tianjin Univ, Sch Life Sci, Tianjin Engn Ctr Micro Nano Biomat & Detect Treat, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China
2.CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
3.Beijing Inst Graph Commun, Beijing Engn Res Ctr Printed Elect, Beijing 102600, Peoples R China
4.Univ Roma Tor Vergata, Dept Biopathol & Imaging Diagnost, I-00133 Rome, Italy
5.Univ Roma Tor Vergata, Dept Expt Med & Surg, I-00133 Rome, Italy
推荐引用方式
GB/T 7714		 Chen, Jing,Liu, Lu,Motevalli, Seyed Mohammad,et al. Light-triggered retention and cascaded therapy of albumin-based theranostic nanomedicines to alleviate tumor adaptive treatment tolerance[J]. Advanced functional materials,2018,28(17):10.
APA Chen, Jing.,Liu, Lu.,Motevalli, Seyed Mohammad.,Wu, Xiaoli.,Yang, Xiao-Hong.,...&Liang, Xing-Jie.(2018).Light-triggered retention and cascaded therapy of albumin-based theranostic nanomedicines to alleviate tumor adaptive treatment tolerance.Advanced functional materials,28(17),10.
MLA Chen, Jing,et al."Light-triggered retention and cascaded therapy of albumin-based theranostic nanomedicines to alleviate tumor adaptive treatment tolerance".Advanced functional materials 28.17(2018):10.

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