Enhanced anti-tumor efficacy of temozolomide-loaded carboxylated poly(amido-amine) combined with photothermal/photodynamic therapy for melanoma treatment
文献类型：期刊论文
| 作者 | Tang, Jianqin1; Zhou, Huige2; Hou, Xiaoyang1; Wang, Liming2; Li, Yaxi1; Pang, Yanyu1; Chen, Chunying2; Jiang, Guan1; Liu, Yanqun1 |
| 刊名 | Cancer letters
 |
| 出版日期 | 2018 |
| 卷号 | 423页码:16-26 |
| ISSN号 | 0304-3835 |
| 关键词 | Melanoma Photothermal therapy Photodynamic therapy Indocyanine green Temozolomide |
| DOI | 10.1016/j.canlet.2018.03.002 |
| 通讯作者 | Chen, chunying(chenchy@nanoctr.cn) ; Jiang, guan(dr.guanjiang@gmail.com) |
| 英文摘要 | Chemotherapy is an important treatment for malignant tumors; however, its efficacy and clinical application are limited by its side effects and drug resistance properties. chemotherapy and phototherapy exhibit synergistic anti-tumor effects. in the present study, a carboxylated poly(amido-amine) (pamam) with low cytotoxicity was synthesized as a delivery nanocarrier for loading chemotherapeutic drugs, temozolomide (tmz), and fluorescent dye indocyanine green (icg). hyaluronic acid (ha), which targets the cd44-overexpressing cancer cells, was modified on the nanocarrier surface to enhance the selective killing of melanoma cells. temperature effect and singlet oxygen production experiments showed that the icg-loaded nanoparticles exhibited good capability to generate heat and singlet oxygen under near-infrared (nir) light (808 nm) irradiation. in vivo imaging measurement confirmed that the icg-encapsulated nanoparticle was delivered successfully and effectively accumulated in the tumor site. in vitro and in vivo experiments revealed that the joint application of tmz- and icg-loaded nanoparticle can kill melanoma cells and suppress growth after nir light irradiation. thus, ha-modified carboxylated pamam loaded with tmz and icg serves as a promising nanoplatform for melanoma treatment. (c) 2018 elsevier b.v. all rights reserved. |
| WOS关键词 | PHOTODYNAMIC TUMOR-THERAPY ; INDOCYANINE-GREEN ; CANCER-THERAPY ; DRUG-DELIVERY ; LUNG-CANCER ; IN-VIVO ; GENE DELIVERY ; BREAST-CANCER ; NANOPARTICLES ; CHEMOTHERAPY |
| WOS研究方向 | Oncology |
| WOS类目 | Oncology |
| 语种 | 英语 |
| 出版者 | ELSEVIER IRELAND LTD |
| WOS记录号 | WOS:000430625100003 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178183 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Chen, Chunying; Jiang, Guan |
| 作者单位 | 1.Xuzhou Med Univ, Dept Dermatol, Affiliated Hosp, Xuzhou 221002, Peoples R China 2.Natl Cencter Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Jianqin,Zhou, Huige,Hou, Xiaoyang,et al. Enhanced anti-tumor efficacy of temozolomide-loaded carboxylated poly(amido-amine) combined with photothermal/photodynamic therapy for melanoma treatment[J]. Cancer letters,2018,423:16-26. |
| APA | Tang, Jianqin.,Zhou, Huige.,Hou, Xiaoyang.,Wang, Liming.,Li, Yaxi.,...&Liu, Yanqun.(2018).Enhanced anti-tumor efficacy of temozolomide-loaded carboxylated poly(amido-amine) combined with photothermal/photodynamic therapy for melanoma treatment.Cancer letters,423,16-26. |
| MLA | Tang, Jianqin,et al."Enhanced anti-tumor efficacy of temozolomide-loaded carboxylated poly(amido-amine) combined with photothermal/photodynamic therapy for melanoma treatment".Cancer letters 423(2018):16-26. |
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