Targeted peptide-au cluster binds to epidermal growth factor receptor (egfr) in both active and inactive states: a clue for cancer inhibition through dual pathways
文献类型：期刊论文
| 作者 | Zhang, Peng1,2; Zhai, Jiao2; Gao, Xueyun3; Zhao, Hongkang1; Su, Wenyong1; Zhao, Lina2 |
| 刊名 | Science bulletin
 |
| 出版日期 | 2018-03-30 |
| 卷号 | 63期号:6页码:349-355 |
| 关键词 | Peptide-au cluster Egfr Targeted binding Anticancer |
| ISSN号 | 2095-9273 |
| DOI | 10.1016/j.scib.2018.02.007 |
| 通讯作者 | Zhao, lina(linazhao@ihep.ac.cn) |
| 英文摘要 | The epidermal growth factor receptor (egfr) has become an important target protein in anticancer drug development. meanwhile, peptide-au cluster has been proposed as potential targeted nano-drug assembled by targeting peptide. here, we designed and synthesized a novel peptide-au cluster as au(10)peptide(5) to target to egfr. we found au(10)peptide(5) could target to the natural binding sites of all egfrs at membrane in both active and inactive states by molecular simulations. its targeted ability was further verified by the co-localization and blocking experiments. we also study the configuration modifications of both active and inactive egfrs after binding by au(10)peptide(5). for active egfr, the absorbed au(10)peptide(5) might replace the natural ligand in egfr endocytosis process. then, the peptide-au cluster in endochylema could inhibit the cancer relating enzyme activity including thioredoxin reductase1 (trxr1) and induce the oxidative stress mediated apoptosis in tumor cells. for inactive egfr, it was retained in inactive state by au(10)peptide(5) binding to inhibit dimerization of egfr for anticancer. both pathways might be applied in anticancer drug development based on the theoretical and experimental study here. (c) 2018 science china press. published by elsevier b.v. and science china press. all rights reserved. |
| WOS关键词 | THIOREDOXIN REDUCTASE 1 ; ALPHA(IIB)BETA(3) INTEGRIN ; BREAST-CANCER ; TUMOR ; CELLS ; NANOCLUSTERS ; THERAPY ; NANOPARTICLES ; RADIOTHERAPY ; COMPLEXES |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000429784000006 |
| 出版者 | SCIENCE PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178186 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Zhao, Lina |
| 作者单位 | 1.Beijing Inst Technol, Sch Phys, Beijing 100081, Peoples R China 2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China 3.Beijing Univ Technol, Dept Chem & Chem Engn, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Peng,Zhai, Jiao,Gao, Xueyun,et al. Targeted peptide-au cluster binds to epidermal growth factor receptor (egfr) in both active and inactive states: a clue for cancer inhibition through dual pathways[J]. Science bulletin,2018,63(6):349-355. |
| APA | Zhang, Peng,Zhai, Jiao,Gao, Xueyun,Zhao, Hongkang,Su, Wenyong,&Zhao, Lina.(2018).Targeted peptide-au cluster binds to epidermal growth factor receptor (egfr) in both active and inactive states: a clue for cancer inhibition through dual pathways.Science bulletin,63(6),349-355. |
| MLA | Zhang, Peng,et al."Targeted peptide-au cluster binds to epidermal growth factor receptor (egfr) in both active and inactive states: a clue for cancer inhibition through dual pathways".Science bulletin 63.6(2018):349-355. |
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来源：高能物理研究所
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