A tiered experimental approach for characterization and silver release of silver-containing wound dressings
文献类型：期刊论文
| 作者 | Xu, Liming1; Bai, Ru2; Cheng, Xiang1,3; Shao, Anliang1; Chen, Liang1; Qu, Shuxin3; Chen, Chunying2 |
| 刊名 | Journal of biomedical nanotechnology
 |
| 出版日期 | 2018-03-01 |
| 卷号 | 14期号:3页码:564-574 |
| 关键词 | Silver-containing wound dressing Agnps Ag-ions Ag release properties Risk assessment |
| ISSN号 | 1550-7033 |
| DOI | 10.1166/jbn.2018.2534 |
| 通讯作者 | Xu, liming(xuliming@nifdc.org.cn) ; Chen, chunying(chenchy@nanoctr.cn) |
| 英文摘要 | Silver-containing dressings are widely used for wound care owing to their broad-spectrum microbicidal activity. however, the potential adverse effects on human health emerging from exposure to their active ingredients (silver ions or nanoparticles) have resulted in widespread concerns about their use. the release profiles of various chemical forms of silver (ag) from silver-containing dressing are closely related to their bioavailability and potential adverse effects on the body. in this research, we demonstrated a tiered experimental approach for systematic characterization and assessment of silver-containing wound dressing, which provides information for risk assessments. the combination of scanning electron microscopy, transmission electron microscopy and energy dispersive x-ray, x-ray photoelectron spectroscopy, and x-ray diffraction allowed for systematic characterization of silver-containing dressings including their morphology, size, composition, valence state, and crystal forms, which have a close relationship with their silver release profile, antimicrobial activity, and potential toxicity. we developed an ag release experiment using a reciprocating holder method and an ultrafiltration membrane column to separate the silver nanoparticles (agnps) and silver ions released from the dressing. furthermore, by adjusting the ag-ion concentration in the release media (simulated body fluid) we could effectively eliminate the interference from agcl particles, which have a similar size to the agnps. we used our method to analyze the release profiles and the chemical form of the ag present in three commercial silver-containing dressings. a large variation in the total ag content, amount of released ag-ions, and amount of released agnps was observed in the three dressings that were tested. the silver release profiles were highly dependent on the crystal structures, surface coating process, and binding modes. the cytotoxicity assays were consistent with the characterization data. this tiered approach provides valuable information of optimized agnps usage and proper manufacturing process for further safe applications. this study establishes a systematic characterization methodology for better understanding of risk assessment of nano-embeded consumer products. |
| WOS关键词 | RANDOMIZED CONTROLLED-TRIAL ; VENOUS LEG ULCERS ; CHLAMYDOMONAS-REINHARDTII ; BACTERIAL CELLULOSE ; GREEN SYNTHESIS ; ACUTE TOXICITY ; VULCAN TRIAL ; CELL-LINE ; NANOPARTICLES ; CYTOTOXICITY |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000430286300011 |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178187 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Xu, Liming; Chen, Chunying |
| 作者单位 | 1.Natl Inst Food & Drug Control, Beijing 102629, Peoples R China 2.Natl Ctr Nanosci & Technol China, Beijing Key Lab Ambient Particles Hlth Effects &, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Southwest Jiaotong Univ, Sch Mat Sci & Engn, Chengdu 610031, Sichuan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Liming,Bai, Ru,Cheng, Xiang,et al. A tiered experimental approach for characterization and silver release of silver-containing wound dressings[J]. Journal of biomedical nanotechnology,2018,14(3):564-574. |
| APA | Xu, Liming.,Bai, Ru.,Cheng, Xiang.,Shao, Anliang.,Chen, Liang.,...&Chen, Chunying.(2018).A tiered experimental approach for characterization and silver release of silver-containing wound dressings.Journal of biomedical nanotechnology,14(3),564-574. |
| MLA | Xu, Liming,et al."A tiered experimental approach for characterization and silver release of silver-containing wound dressings".Journal of biomedical nanotechnology 14.3(2018):564-574. |
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来源：高能物理研究所
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