Rapid detection of copper in biological systems using click chemistry
文献类型：期刊论文
| 作者 | Zheng, Wenshu1,2,3,4; Li, Huiling5; Chen, Wenwen1,2,3,6; Zhang, Jiangjiang1,2,3; Wang, Nuoxin1,2,3; Guo, Xuefeng4; Jiang, Xingyu1,2,3 |
| 刊名 | Small
 |
| 出版日期 | 2018-04-05 |
| 卷号 | 14期号:14页码:8 |
| 关键词 | Click chemistry Cu detection Graphene |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201703857 |
| 通讯作者 | Jiang, xingyu(xingyujiang@nanoctr.cn) |
| 英文摘要 | A fast (1 min), straightforward but efficient, click chemistry-based system that enables the rapid detection of free copper (cu) ions in either biological fluids or living cells without tedious pretreatment is provided. cu can quickly induce the conjugation between graphene oxide (go) and a fluorescent dye via click reaction. on the basis of the high specificity of bioorthogonal reaction and the effective quenching ability of go, the assay studied in this paper can respond to cu ions in less than 1 min with excellent selectivity and sensitivity, which is the fastest sensor for cu as far as it is known. in addition, the application of this system is verified by performing assays in living cells and untreated urine samples from patients suffering from wilson's disease. such a cu detection system shows great promises in both fundamental research and routine clinical diagnostics. |
| WOS关键词 | RESONANCE ENERGY-TRANSFER ; FUNCTIONALIZED GOLD NANOPARTICLES ; SYNTHETIC FLUORESCENT-PROBES ; GRAPHENE OXIDE ; WILSON-DISEASE ; IN-VIVO ; SENSOR ; IONS ; TRAFFICKING ; GLUTATHIONE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000429579100012 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2178191 |
| 专题 | 高能物理研究所 |
| 通讯作者 | Jiang, Xingyu |
| 作者单位 | 1.Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, Beijing Engn Res Ctr BioNanotechnol, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China 2.Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sinodanish Coll, 19 A Yuquan Rd, Beijing 100049, Peoples R China 4.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China 5.Capital Med Univ, Beijing Chao Yang Hosp, Dept Occupat Med & Clin Toxicol, 8 Gongren Tiyuchang Nanlu, Beijing 100020, Peoples R China 6.Shenzhen Univ, Med Sch, Dept Biomed Engn, Shenzhen 518020, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Wenshu,Li, Huiling,Chen, Wenwen,et al. Rapid detection of copper in biological systems using click chemistry[J]. Small,2018,14(14):8. |
| APA | Zheng, Wenshu.,Li, Huiling.,Chen, Wenwen.,Zhang, Jiangjiang.,Wang, Nuoxin.,...&Jiang, Xingyu.(2018).Rapid detection of copper in biological systems using click chemistry.Small,14(14),8. |
| MLA | Zheng, Wenshu,et al."Rapid detection of copper in biological systems using click chemistry".Small 14.14(2018):8. |
入库方式： iSwitch采集
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。