Syntheses of Fluorescence Probe 5-[2-(1H-imlidazol-1-yl)-2-oxoethyl] benzo[b]acridin-12(5H)-one and Its Application for the Determination of Aliphatic Amines with LC-APCI-MS
文献类型：期刊论文
| 作者 | Fu Yan-Yan2; Sun Zhi-Wei1,3; Zhao Huai-Xin2; Bai Xin-Wei2; Suo You-Rui1; Li Yu-Lin1; You Jin-Mao1,2 |
| 刊名 | chemical journal of chinese universities-chinese
 |
| 出版日期 | 2009-11-10 |
| 卷号 | 30期号:11页码:2146-2153 |
| 关键词 | High performance liquid chromatography/ion-trap mass spectrometry Percent ionization 2-{12-Oxobenzo[b] acridin-5 (12H)-yl]-acetic acid 5-[2-(1H-imidazol-1-yl)-2-oxoethyl] benzo [b] acridin-12 (5H)-one |
| ISSN号 | 0251-0790 |
| 中文摘要 | 2-{12-oxobenzo[b] acridin-5(12h)-yl} -acetic acid (baaa) reacted with coupling agent n, n'-carbonyldiimidazole (cdi) to form an activated amide intermediate 5-[2-(1h-imidazol-1-yl)-2-oxoethyl] benzo[b]acridin-12(5h)-one(ieba), which was a novel fluorescence probe. the amide intermediate(ieba) reacted preferably with amines in dmf solvent in the absence of catalysts to give the high yields of derivatives, which not only have high fluorescence sensitivity but also have strong ionizable ability. the optimum excitation and emission wavelengths were at lambda(ex)/lambda(em) = 272 nm/505 nm. the percent ionization 8 values in aqueous acetonitrile and aqueous methanol were in the range of 0-57. 32% and 0-62. 14%, respectively. the fluorescence detection limits of twelve amine derivatives(at a signal-to-noise ratio of 3) were in the range of 0. 15-0. 50 ng/ml. the online apci-ms detection limits were at levels of 1. 43-8. 51 ng/ml(s/n = 3). |
| 英文摘要 | 2-{12-oxobenzo[b] acridin-5(12h)-yl} -acetic acid (baaa) reacted with coupling agent n, n'-carbonyldiimidazole (cdi) to form an activated amide intermediate 5-[2-(1h-imidazol-1-yl)-2-oxoethyl] benzo[b]acridin-12(5h)-one(ieba), which was a novel fluorescence probe. the amide intermediate(ieba) reacted preferably with amines in dmf solvent in the absence of catalysts to give the high yields of derivatives, which not only have high fluorescence sensitivity but also have strong ionizable ability. the optimum excitation and emission wavelengths were at lambda(ex)/lambda(em) = 272 nm/505 nm. the percent ionization 8 values in aqueous acetonitrile and aqueous methanol were in the range of 0-57. 32% and 0-62. 14%, respectively. the fluorescence detection limits of twelve amine derivatives(at a signal-to-noise ratio of 3) were in the range of 0. 15-0. 50 ng/ml. the online apci-ms detection limits were at levels of 1. 43-8. 51 ng/ml(s/n = 3). |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, multidisciplinary |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | performance liquid-chromatography ; volatile n-nitrosamines ; derivatization ; water ; hplc ; identification ; products ; reagent |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000272832200010 |
| 公开日期 | 2011-12-13 |
| 源URL | [http://ir.nwipb.ac.cn//handle/363003/1806]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Chinese Acad Sci, NW Plateau Inst Biol, Xining 810001, Peoples R China 2.Qufu Normal Univ, Sch Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu Yan-Yan,Sun Zhi-Wei,Zhao Huai-Xin,et al. Syntheses of Fluorescence Probe 5-[2-(1H-imlidazol-1-yl)-2-oxoethyl] benzo[b]acridin-12(5H)-one and Its Application for the Determination of Aliphatic Amines with LC-APCI-MS[J]. chemical journal of chinese universities-chinese,2009,30(11):2146-2153. |
| APA | Fu Yan-Yan.,Sun Zhi-Wei.,Zhao Huai-Xin.,Bai Xin-Wei.,Suo You-Rui.,...&You Jin-Mao.(2009).Syntheses of Fluorescence Probe 5-[2-(1H-imlidazol-1-yl)-2-oxoethyl] benzo[b]acridin-12(5H)-one and Its Application for the Determination of Aliphatic Amines with LC-APCI-MS.chemical journal of chinese universities-chinese,30(11),2146-2153. |
| MLA | Fu Yan-Yan,et al."Syntheses of Fluorescence Probe 5-[2-(1H-imlidazol-1-yl)-2-oxoethyl] benzo[b]acridin-12(5H)-one and Its Application for the Determination of Aliphatic Amines with LC-APCI-MS".chemical journal of chinese universities-chinese 30.11(2009):2146-2153. |
入库方式： OAI收割
来源：西北高原生物研究所
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