中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 西北高原生物研究所
  3. 中国科学院西北高原生物研究所
Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization

文献类型：期刊论文

作者Qu, Jiapeng1,2; Lin, Qiang3; Wang, Guanhong4; Li, Xiangzhen5; Li, Tongtong6; Li, Huan7
刊名FRONTIERS IN MICROBIOLOGY
出版日期2018-07-31
卷号9
关键词Gut Microbiota Urbanization Beta Diversity Network Interaction Environmental Filtering Lifestyle
ISSN号1664-302X
DOI10.3389/fmicb.2018.01745
文献子类Article
英文摘要Urbanization is associated with shifts in human lifestyles, thus possibly influencing the diversity, interaction and assembly of gut microbiota. However, the question regarding how human gut microbiota adapts to varying lifestyles remains elusive. To understand the relationship between gut microbiota and urbanization, we compared the diversity, interaction and assembly of gut microbial communities of herdsmen from three regions with different levels of urbanization, namely traditional herdsmen (TH), semi-urban herdsmen (SUH) and urban herdsmen (UH). The relative abundance of Prevotella decreased with the degree of urbanization (from TH to UH), whereas that of Bacteroides, Faecalibacterium, and Blautia showed an opposite trend. Although the alpha diversity measures (observed OTUs and phylogenetic diversity) of gut microbiota were unaffected by urbanization, the beta diversity (Jaccard or Bray-Curtis distances) was significantly influenced by urbanization. Metagenome prediction revealed that the gene functions associated with metabolism (i.e., carbohydrate and lipid metabolism) had significant differences between TH and UH. Network analysis showed that the modularity increased with the degree of urbanization, indicating a high extent of niche differentiation in UH. Meanwhile the trend of network density was opposite, indicating a more complex network in TH. Notably, the relative importance of environmental filtering that governed the community assembly increased with the degree of urbanization, which indicated that deterministic factors (e.g , low-fiber diet) play more important roles than stochastic factors (e.g., stochastic dispersal) in shaping the gut microbiota. A quantification of ecological processes showed a stronger signal of variable selection in UH than TH, implying that different selective pressures cause divergent gut community compositions due to urban lifestyles. Our results suggest that beta diversity, network interactions and ecological processes of gut microbiota may reflect the degree of urbanization, and highlight the adaptation of human gut microbiota to lifestyle changes.
WOS关键词ECOLOGICAL PROCESSES ; ASSEMBLY PROCESSES ; NEUTRAL THEORY ; DIVERSITY ; COMMUNITIES ; PATTERNS ; SUCCESSION ; GRADIENTS ; SEQUENCES ; ECOSYSTEM
WOS研究方向Microbiology
语种英语
WOS记录号WOS:000440311400001
出版者FRONTIERS MEDIA SA
资助机构Fundamental Research Funds for the Central Universities(lzujbky-2018-68) ; National Natural Science foundation of China(31770459 ; Youth Innovation Promotion Association CAS ; CAS "Light of West China" Program ; Construction Fund for Qinghai Key Laboratories(2017-ZJ-Y20) ; Zhejiang Provincial Natural Science Foundation of China(LY18E090010) ; 31670503)
源URL[http://ir.nwipb.ac.cn/handle/363003/13774]  
专题西北高原生物研究所_中国科学院西北高原生物研究所
通讯作者Qu, Jiapeng; Li, Xiangzhen
作者单位1.Qinghai Prov Key Lab Restorat Ecol Cold Reg, Xining, Qinghai, Peoples R China
2.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining, Qinghai, Peoples R China
3.Czech Acad Sci, Inst Soil Biol, Ceske Budejovice, Czech Republic
4.Harvard Univ, Rowland Inst Harvard, Cambridge, MA 02138 USA
5.Chinese Acad Sci, Key Lab Environm & Appl Microbiol, Environm Microbiol Key Lab Sichuan Prov, Chengdu Inst Biol, Chengdu, Sichuan, Peoples R China
6.Zhejiang Univ Technol, Dept Appl Biol, Coll Biotechnol & Bioengn, Hangzhou, Zhejiang, Peoples R China
7.Lanzhou Univ, Inst Occupat Hlth & Environm Hlth, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China
推荐引用方式
GB/T 7714		 Qu, Jiapeng,Lin, Qiang,Wang, Guanhong,et al. Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization[J]. FRONTIERS IN MICROBIOLOGY,2018,9.
APA Qu, Jiapeng,Lin, Qiang,Wang, Guanhong,Li, Xiangzhen,Li, Tongtong,&Li, Huan.(2018).Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization.FRONTIERS IN MICROBIOLOGY,9.
MLA Qu, Jiapeng,et al."Gut Microbiota in Tibetan Herdsmen Reflects the Degree of Urbanization".FRONTIERS IN MICROBIOLOGY 9(2018).

入库方式： OAI收割

来源：西北高原生物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。