中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 西北高原生物研究所
  3. 中国科学院西北高原生物研究所
The novel 22 bp insertion mutation in a promoter region of the PITX2 gene is associated with litter size and growth traits in goats

文献类型：期刊论文

作者Qu, Lei3,4; Liu, Jinwang3,4; Hu, Linyong1; Zhu, Haijing3,4; Jiang, Enhui2; Yan, Hailong2,3,4
刊名ARCHIVES ANIMAL BREEDING
出版日期2018-08-09
卷号61期号:3页码:329-336
ISSN号0003-9438
DOI10.5194/aab-61-329-2018
文献子类Article
英文摘要The paired-like homeodomain 2 (PITX2) gene plays a critical role in regulating development, reproduction, and growth traits in ruminants. Hence, the objective of this study was to explore the polymorphisms of this gene and to evaluate their associations with quantitative traits. Herein, a novel insertion in the promoter region of the PITX2 gene was reported in Shaanbei white cashmere (SBWC) goats (n = 1012). The genotype distributions between mothers of single-kid and multi-kid groups within SBWC goats were significantly different (P < 0.01), implying that this indel mutation might affect the litter size. Furthermore, association analysis found that this indel mutation was significantly associated with litter size (P = 0.001). Individuals with genotype DD had a significantly smaller litter size than those with other genotypes (P < 0.01). Besides, this indel was significantly associated with the body length (P = 0.042) and the chest width (P = 0.031). Especially, the individuals with genotype DD had a significantly lower body length than those with genotype II (P < 0.05), which was consistent with the trend in litter size. These findings suggested that the new 22 bp indel mutation within the PITX2 gene is significantly associated with litter size and growth traits; this can be utilized as a functional molecular marker in goat breeding.
WOS关键词AXENFELD-RIEGER SYNDROME ; ATRIAL-FIBRILLATION ; INDEL ; TRANSCRIPTION ; IDENTIFICATION ; EXPRESSION ; SHEEP
WOS研究方向Agriculture
语种英语
出版者COPERNICUS GESELLSCHAFT MBH
WOS记录号WOS:000441170300001
资助机构National Natural Science Foundation of China(31760650 ; Provincial Key Projects of Shaanxi(2014KTDZ02-01) ; Applied Basic Research Program of Qinghai Province(2014-ZJ-710) ; West Light Foundation of The Chinese Academy of Sciences ; 31702115)
源URL[http://ir.nwipb.ac.cn/handle/363003/13784]  
专题西北高原生物研究所_中国科学院西北高原生物研究所
通讯作者Qu, Lei
作者单位1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Qinghai, Peoples R China
2.Northwest A&F Univ, Coll Anim Sci & Technol, Shaanxi Key Lab Mol Biol Agr, Yangling 712100, Shaanxi, Peoples R China
3.Yulin Univ, Life Sci Res Ctr, Yulin 719000, Peoples R China
4.Yulin Univ, Shaanxi Prov Engn & Technol Res Ctr Cashmere Goat, Yulin 719000, Peoples R China
推荐引用方式
GB/T 7714		 Qu, Lei,Liu, Jinwang,Hu, Linyong,et al. The novel 22 bp insertion mutation in a promoter region of the PITX2 gene is associated with litter size and growth traits in goats[J]. ARCHIVES ANIMAL BREEDING,2018,61(3):329-336.
APA Qu, Lei,Liu, Jinwang,Hu, Linyong,Zhu, Haijing,Jiang, Enhui,&Yan, Hailong.(2018).The novel 22 bp insertion mutation in a promoter region of the PITX2 gene is associated with litter size and growth traits in goats.ARCHIVES ANIMAL BREEDING,61(3),329-336.
MLA Qu, Lei,et al."The novel 22 bp insertion mutation in a promoter region of the PITX2 gene is associated with litter size and growth traits in goats".ARCHIVES ANIMAL BREEDING 61.3(2018):329-336.

入库方式： OAI收割

来源：西北高原生物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。