The involvement of iron in chemerin induced cell cycle arrest in human hepatic carcinoma SMMC7721 cells
文献类型：期刊论文
| 作者 | Shi, Ping1,2; Peng, Min1 ; Sun, Jing1; Wang, Jian2; Wang, Song2; Sun, Pengcheng2
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| 刊名 | METALLOMICS
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| 出版日期 | 2018-06-01 |
| 卷号 | 10期号:6页码:838-845 |
| ISSN号 | 1756-5901 |
| DOI | 10.1039/c8mt00099a |
| 文献子类 | Article |
| 英文摘要 | Chemerin exhibits a tumor-inhibitory role in hepatocellular carcinoma. However, the effect of chemerin on essential metal elements in hepatic cells remains unclear. In our study, the contents of six important metal ions, including potassium, calcium, sodium, magnesium, iron and zinc, were detected in human hepatoma SMMC7721 and immortal hepatic QSG7701 cells by ICP-AES. The data showed that chemerin only decreases the content of intracellular iron in SMMC7721 cells. The reduction was due to the blockage of iron entry through the decrease in the mRNA levels of divalent metal transporter 1, iron regulatory proteins and transferrin receptors. Furthermore, the reduction of the cellular iron content induced alterations of p53-p27-p21 signaling to arrest the cell cycle at S phase in SMMC7721 cells treated by chemerin. Conversely, iron addition led to recovery from the inhibitory effect of chemerin on SMMC7721 cells. The results suggest that chemerin plays an important role in inhibiting the cell proliferation of hepatocellular carcinomas by interfering with cellular iron homeostasis in this type of tumors. |
| WOS关键词 | TRANSFERRIN-BOUND IRON ; DENDRITIC CELLS ; PROTEIN-LEVELS ; RECEPTOR ; METABOLISM ; CANCER ; LIVER ; HEPATOCYTES ; EXPRESSION ; COMPLEX |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000436031100006 |
| 资助机构 | National Natural Science Foundation of China(31671309) ; Development Project of Qinghai Key Laboratory(2017-ZJ-Y10) |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/13786]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 通讯作者 | Shi, Ping; Sun, Jing |
| 作者单位 | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Qinghai Tibet Plateau Biol Resour, Xiguan Ave 59, Xining 810001, Qinghai, Peoples R China 2.East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Ping,Peng, Min,Sun, Jing,et al. The involvement of iron in chemerin induced cell cycle arrest in human hepatic carcinoma SMMC7721 cells[J]. METALLOMICS,2018,10(6):838-845. |
| APA | Shi, Ping,Peng, Min,Sun, Jing,Wang, Jian,Wang, Song,&Sun, Pengcheng.(2018).The involvement of iron in chemerin induced cell cycle arrest in human hepatic carcinoma SMMC7721 cells.METALLOMICS,10(6),838-845. |
| MLA | Shi, Ping,et al."The involvement of iron in chemerin induced cell cycle arrest in human hepatic carcinoma SMMC7721 cells".METALLOMICS 10.6(2018):838-845. |
入库方式： OAI收割
来源：西北高原生物研究所
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