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An antioxidant alpha-glucan from Cladina rangiferina (L) Nyl. and its protective effect on alveolar epithelial cells from Pb2+-induced oxidative damage

文献类型：期刊论文

作者Bi, Hongtao5; Gao, Tingting4; Du, Yuzhi4,5; Yang, Hongxia4,5; Li, Cen4,5; Song, Jiayin1; Wei, Lixin4,5; Ma, Jianbin2; Huang, Xiaojuan3,4,5
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
出版日期2018-06-01
卷号112页码:101-109
关键词Cladina Rangiferina (l) Nyl. Alpha-glucan Antioxidant Activity Alveolar Epithelium Cell pb2+-oxidative Toxicity Protection
ISSN号0141-8130
DOI10.1016/j.ijbiomac.2018.01.154
文献子类Article
英文摘要Air pollution is a serious global health problem nowadays. So, it is an emergency to pay sufficient attention to treat and prevent the diseases caused by air pollution, especially respiratory disease and lung damage. Cladina rangiferina (L) Nyl. is an edible lichen that has been used in medicinal diets to treat respiratory and other diseases for over 500 years. In this study, a water-soluble polysaccharide, CRWP-P, was obtained from C rangiferina by hot-water extraction, freeze-thawing separation, and Fehling reagent purification. Structural analysis showed that CRWP-P is a linear alpha-(1 -> 3),(1 -> 4)-D-glucan without branches. Its Mw was determined to be 1.05 x 10(5) Da. Its (1,3)-alpha-D-glucopyranosyl: (1,4)-alpha-D-glucopyranosyl ratio is approximately 1:2. Antioxidant activity assay showed that C. rangiferina polysaccharides, especially CRWP-P. had appreciable DPPH radical-scavenging activity and reducing power. Notably, they could effectively decrease cell breakdown and ROS generation, inhibit lipid peroxidation, increase key antioxidase activity, and promote glutathione redox cycling in Pb2+-oxidative injured A549 alveolar epithelium cells. Overall, the results of this study indicated that C rangiferina polysaccharides, especially CRWP-P, have the potential to be natural antioxidants for the treatment of lung oxidative damage induced by lead of air pollutants. (C) 2018 Elsevier B.V. All rights reserved.
WOS关键词IN-VITRO ANTIOXIDANT ; STRUCTURAL-CHARACTERIZATION ; LIPID-PEROXIDATION ; PARTICULATE MATTER ; CETRARIA-ISLANDICA ; POLYSACCHARIDES ; LICHENS ; DERIVATIVES ; ASSAY ; LEAD
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种英语
WOS记录号WOS:000430522400012
出版者ELSEVIER SCIENCE BV
资助机构National Natural Science Foundation of China(31400310 ; Applying Basic Research Program of Qinghai Province(2015-ZJ-727) ; Key Laboratory Special Development Program of Qinghai Province(2017-ZJ-Y08) ; Natural Science Foundation of Tianjin City(15JCQJC07500) ; 51408405)
源URL[http://ir.nwipb.ac.cn/handle/363003/13832]  
专题西北高原生物研究所_中国科学院西北高原生物研究所
通讯作者Bi, Hongtao; Gao, Tingting
作者单位1.Tianjin Univ, Tianjin Key Lab Architectural Phys & Environm Tec, Tianjin, Peoples R China
2.Qinghai Normal Univ, Sch Life & Geog Sci, Xining, Qinghai, Peoples R China
3.Sichuan Univ, Natl Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China
4.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, 23 Xining Rd, Xining 810008, Qinghai, Peoples R China
5.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, Xining, Qinghai, Peoples R China
推荐引用方式
GB/T 7714		 Bi, Hongtao,Gao, Tingting,Du, Yuzhi,et al. An antioxidant alpha-glucan from Cladina rangiferina (L) Nyl. and its protective effect on alveolar epithelial cells from Pb2+-induced oxidative damage[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,112:101-109.
APA Bi, Hongtao.,Gao, Tingting.,Du, Yuzhi.,Yang, Hongxia.,Li, Cen.,...&Huang, Xiaojuan.(2018).An antioxidant alpha-glucan from Cladina rangiferina (L) Nyl. and its protective effect on alveolar epithelial cells from Pb2+-induced oxidative damage.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,112,101-109.
MLA Bi, Hongtao,et al."An antioxidant alpha-glucan from Cladina rangiferina (L) Nyl. and its protective effect on alveolar epithelial cells from Pb2+-induced oxidative damage".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 112(2018):101-109.

入库方式： OAI收割

来源：西北高原生物研究所

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