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Efficient Separation of Four Antibacterial Diterpenes from the Roots of Salvia Prattii Using Non-Aqueous Hydrophilic Solid-Phase Extraction Followed by Preparative High-Performance Liquid Chromatography

文献类型：期刊论文

作者Shao, Yun2,3; Tao, Yanduo2,3; Wang, Qilan2,3; Mei, Lijuan2,3; Jiao, Lijin2,3; Wang, Weidong2,3; Liu, Zenggen2,3; Yue, Huilan2,3; Pei, Jinjin1,3; Cui, Yulei2,3
刊名MOLECULES
出版日期2018-03-01
卷号23期号:3
关键词Salvia Prattii Antibacterial Diterpenes Hydrophilic Solid-phase Extraction Preparative High-performance Liquid Chromatography
ISSN号1420-3049
DOI10.3390/molecules23030623
文献子类Article
英文摘要An efficient preparative procedure for the separation of four antibacterial diterpenes from a Salvia prattii crude diterpenes-rich sample was developed. Firstly, the XION hydrophilic stationary phase was chosen to separate the antibacterial crude diterpenes-rich sample (18.0 g) into three fractions with a recovery of 46.1%. Then, the antibacterial fractions I (200 mg), II (200 mg), and III (150 g) were separated by the Megress C18 preparative column, and compounds tanshinone IIA (80.0 mg), salvinolone (62.0 mg), cryptotanshinone (70.0 mg), and ferruginol (68.0 mg) were produced with purities greater than 98%. The procedure achieved large-scale preparation of the four diterpenes with high purity, and it could act as a reference for the efficient preparation of active diterpenes from other plant extracts.
WOS关键词COUNTER-CURRENT CHROMATOGRAPHY ; MILTIORRHIZA-BUNGE ; TANSHINONES ; PURIFICATION ; CELLS
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000428514100114
出版者MDPI
资助机构High and New Technology Research and Development Planning, Significant Science & Technological Project of Qinghai Province(2014-GX-A3A) ; Natural Science Funds of Qinghai Province(2016-ZJ-933Q) ; Project of Discovery, Evaluation and Transformation of Active Natural Compounds, Strategic Biological Resources Service Network Programme of Chinese Academy of Sciences(ZSTH-027) ; West Light Foundation of the Chinese Academy of Sciences for Doctors ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2017471)
源URL[http://ir.nwipb.ac.cn/handle/363003/13838]  
专题西北高原生物研究所_中国科学院西北高原生物研究所
通讯作者Shao, Yun; Tao, Yanduo
作者单位1.Shaanxi Univ Technol, Shaanxi Key Lab Bioresources, Hanzhong 723000, Peoples R China
2.Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China
3.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China
推荐引用方式
GB/T 7714		 Shao, Yun,Tao, Yanduo,Wang, Qilan,et al. Efficient Separation of Four Antibacterial Diterpenes from the Roots of Salvia Prattii Using Non-Aqueous Hydrophilic Solid-Phase Extraction Followed by Preparative High-Performance Liquid Chromatography[J]. MOLECULES,2018,23(3).
APA Shao, Yun.,Tao, Yanduo.,Wang, Qilan.,Mei, Lijuan.,Jiao, Lijin.,...&Dang, Jun.(2018).Efficient Separation of Four Antibacterial Diterpenes from the Roots of Salvia Prattii Using Non-Aqueous Hydrophilic Solid-Phase Extraction Followed by Preparative High-Performance Liquid Chromatography.MOLECULES,23(3).
MLA Shao, Yun,et al."Efficient Separation of Four Antibacterial Diterpenes from the Roots of Salvia Prattii Using Non-Aqueous Hydrophilic Solid-Phase Extraction Followed by Preparative High-Performance Liquid Chromatography".MOLECULES 23.3(2018).

入库方式： OAI收割

来源：西北高原生物研究所

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