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Reconstructing the genetic history of late Neanderthals

文献类型：期刊论文

作者Hajdinjak, Mateja1; Fu, Qiaomei2,3,4; Huebner, Alexander1; Petr, Martin1; Mafessoni, Fabrizio1; Grote, Steffi1; Skoglund, Pontus5; Narasimham, Vagheesh5; Rougier, Helene6; Crevecoeur, Isabelle7
刊名NATURE
出版日期2018-03-29
卷号555期号:7698页码:652-+
ISSN号0028-0836
DOI10.1038/nature26151
文献子类Article
英文摘要Although it has previously been shown that Neanderthals contributed DNA to modern humans(1,2), not much is known about the genetic diversity of Neanderthals or the relationship between late Neanderthal populations at the time at which their last interactions with early modern humans occurred and before they eventually disappeared. Our ability to retrieve DNA from a larger number of Neanderthal individuals has been limited by poor preservation of endogenous DNA(3) and contamination of Neanderthal skeletal remains by large amounts of microbial and present-day human DNA(3-5). Here we use hypochlorite treatment(6) of as little as 9 mg of bone or tooth powder to generate between 1- and 2.7-fold genomic coverage of five Neanderthals who lived around 39,000 to 47,000 years ago (that is, late Neanderthals), thereby doubling the number of Neanderthals for which genome sequences are available. Genetic similarity among late Neanderthals is well predicted by their geographical location, and comparison to the genome of an older Neanderthal from the Caucasus(2,7) indicates that a population turnover is likely to have occurred, either in the Caucasus or throughout Europe, towards the end of Neanderthal history. We find that the bulk of Neanderthal gene flow into early modern humans originated from one or more source populations that diverged from the Neanderthals that were studied here at least 70,000 years ago, but after they split from a previously sequenced Neanderthal from Siberia(2) around 150,000 years ago. Although four of the Neanderthals studied here post-date the putative arrival of early modern humans into Europe, we do not detect any recent gene flow from early modern humans in their ancestry.
WOS关键词MITOCHONDRIAL GENOME SEQUENCE ; ANCIENT DNA ; DENISOVA CAVE ; MODERN HUMANS ; DAMAGED DNA ; SIBERIA ; POPULATIONS ; HOMININ ; CONTAMINATION ; EVOLUTIONARY
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000428617600048
出版者NATURE PUBLISHING GROUP
源URL[http://119.78.100.205/handle/311034/8755]  
专题中国科学院古脊椎动物与古人类研究所
通讯作者Hajdinjak, Mateja; Paeaebo, Svante; Kelso, Janet
作者单位1.Max Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany
2.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins Chinese, IVPP, Beijing 100044, Peoples R China
3.CAS Ctr Excellence Life & Paleoenvironm, Beijing 100044, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Harvard Med Sch, Dept Genet, Boston, MA 02115 USA
6.Calif State Univ Northridge, Dept Anthropol, Northridge, CA 91330 USA
7.Univ Bordeaux, CNRS, UMR PACEA 5199, F-33615 Pessac, France
8.Royal Belgian Inst Nat Sci, B-1000 Brussels, Belgium
9.Leiden Univ, Fac Archaeol, NL-2300 RA Leiden, Netherlands
10.Max Planck Inst Evolutionary Anthropol, Dept Human Evolut, D-04103 Leipzig, Germany
推荐引用方式
GB/T 7714		 Hajdinjak, Mateja,Fu, Qiaomei,Huebner, Alexander,et al. Reconstructing the genetic history of late Neanderthals[J]. NATURE,2018,555(7698):652-+.
APA Hajdinjak, Mateja.,Fu, Qiaomei.,Huebner, Alexander.,Petr, Martin.,Mafessoni, Fabrizio.,...&Kelso, Janet.(2018).Reconstructing the genetic history of late Neanderthals.NATURE,555(7698),652-+.
MLA Hajdinjak, Mateja,et al."Reconstructing the genetic history of late Neanderthals".NATURE 555.7698(2018):652-+.

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来源：古脊椎动物与古人类研究所

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