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  2. 地质与地球物理研究所
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  4. 中国科学院地球与行星物理重点实验室
Positive magnetic resonance angiography using ultrafine ferritin-based iron oxide nanoparticles

文献类型：期刊论文

作者Cai, Yao1,2,3; Wang, Yuqing4; Xu, Huangtao1,2,3,5; Cao, Changqian1,2,3; Zhu, Rixiang3; Tang, Xu6; Zhang, Tongwei1,2; Pan, Yongxin1,2,3,5
刊名NANOSCALE
出版日期2019-02-14
卷号11期号:6页码:2644-2654
ISSN号2040-3364
DOI10.1039/c8nr06812g
英文摘要Iron oxide nanoparticles with good biocompatibility can serve as safe magnetic resonance imaging contrast agents. Herein, we report that ultrafine ferritin-based iron oxide (hematite/maghemite) nanoparticles synthesized by controlled biomimetic mineralization using genetically recombinant human H chain ferritin can be used as a positive contrast agent in magnetic resonance angiography. The synthesized magnetoferritin with an averaged core size of 2.2 +/- 0.7 nm (hereafter named M-HFn-2.2) shows a r1 value of 0.86 mM(-1) s(-1) and a r2/r1 ratio of 25.1 at a 7 T magnetic field. Blood pool imaging on mice using the M-HFn-2.2 nanoparticles that were injected through a tail vein by single injection at a dose of 0.54 mM Fe per kg mouse body weight enabled detecting detailed vascular nets at 3 minutes post-injection; the MR signal intensity continuously enhanced up to 2 hours post-injection, which is much longer than that of the commercial magnevist (Gd-DTPA) contrast. Moreover, biodistribution examination indicates that organs such as liver, spleen and kidney safely cleared the injected nanoparticles within one day after the injection, demonstrating no risk of iron overload in test mice. Therefore, this study sheds light on developing high-performance gadolinium free positive magnetic resonance contrast agents for biomedical applications.
WOS关键词T-1 CONTRAST AGENTS ; H-FERRITIN ; GADOLINIUM DEPOSITION ; PROTEIN ; FERUMOXYTOL ; PHARMACOKINETICS ; DIAGNOSIS ; NANOCAGES ; PLATFORM ; TUMORS
资助项目National Natural Science Foundation of China[41621004] ; National Natural Science Foundation of China[41704072] ; National Natural Science Foundation of China[41330104] ; National Natural Science Foundation of China[41574062] ; Key Program of Chinese Academy of Sciences[QYZDJ-SSW-DQC024] ; China Postdoctoral Science Foundation[2017M610979]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000459579400048
出版者ROYAL SOC CHEMISTRY
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation
源URL[http://ir.iggcas.ac.cn/handle/132A11/90673]  
专题地质与地球物理研究所_中国科学院地球与行星物理重点实验室
通讯作者Cai, Yao; Pan, Yongxin
作者单位1.Chinese Acad Sci, Inst Geol & Geophys, Biogeomagnetism Grp, Key Lab Earth & Planetary Phys, Beijing 100029, Peoples R China
2.Chinese Acad Sci, France China Int Lab Evolut & Dev Magnetotact Mul, Beijing 100029, Peoples R China
3.Chinese Acad Sci, Inst Geol & Geophys, PGL, Beijing 100029, Peoples R China
4.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Inst Earth Sci, Transmiss Electron Microscope Lab, Beijing 100029, Peoples R China
推荐引用方式
GB/T 7714		 Cai, Yao,Wang, Yuqing,Xu, Huangtao,et al. Positive magnetic resonance angiography using ultrafine ferritin-based iron oxide nanoparticles[J]. NANOSCALE,2019,11(6):2644-2654.
APA Cai, Yao.,Wang, Yuqing.,Xu, Huangtao.,Cao, Changqian.,Zhu, Rixiang.,...&Pan, Yongxin.(2019).Positive magnetic resonance angiography using ultrafine ferritin-based iron oxide nanoparticles.NANOSCALE,11(6),2644-2654.
MLA Cai, Yao,et al."Positive magnetic resonance angiography using ultrafine ferritin-based iron oxide nanoparticles".NANOSCALE 11.6(2019):2644-2654.

入库方式： OAI收割

来源：地质与地球物理研究所

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