Prevalence and Clinical Correlates of and Cognitive Function at the Time of Suicide Attempts in First-Episode and Drug-Naive Patients With Schizophrenia
文献类型：期刊论文
| 作者 | Zhang, Xiang Yang1,2; Du, Xiangdong3; Yin, Guangzhong3; Zhang, Yingyang3; Chen, Dachun4; Xiu, Meihong4; Wang, Changhong5; Zhang, Ruilong5; Cassidy, Ryan M.2; Ning, Yuping6 |
| 刊名 | JOURNAL OF CLINICAL PSYCHIATRY
 |
| 出版日期 | 2018-07-01 |
| 卷号 | 79期号:4页码:8 |
| ISSN号 | 0160-6689 |
| 关键词 | Suicide Schizophrenia |
| DOI | 10.4088/JCP.17m11797 |
| 通讯作者 | Zhang, Xiang Yang(xiang.y.zhang@uth.tmc.edu) |
| 英文摘要 | Background: It is well established that patients with chronic schizophrenia have a substantially higher rate of attempted and completed suicide than the general population. However, the actual prevalence of suicide attempts at first-episode psychosis is relatively unknown. Previous studies showed that suicidal schizophrenia patients demonstrate higher cognitive function than nonsuicidal patients, though with inconsistent results. The aims of the study were to examine the prevalence of suicide attempts and the association of this prevalence with demographic and clinical variables and cognitive function in Chinese first-episode, drug-naive (FEDN) schizophrenia patients using a cross-sectional and case-control design. Method: A total of 357 FEDN inpatients meeting DSM-IV criteria for schizophrenia and 380 healthy controls were enrolled and completed a detailed in-house questionnaire. The suicide attempt data were collected from medical records and interviews with the patients and their family members. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was administered to measure cognition in the 28 patients with and 95 patients without a history of suicide attempt and 151 healthy controls. Also, patients were rated on the Positive and Negative Syndrome Scale (PANSS). This study was conducted from June 2013 to December 2015. Results: A suicide attempt rate of 12.0% was found in inpatients with first-episode schizophrenia. The attempters were more likely to smoke (34.4% vs 17.9%; chi(2) = 5.49, P =.019) and had lower severity of negative symptoms (F-1,F-354 = 4.12, P =.043) as compared to FEDN patients without a suicide attempt. All 5 RBANS subscales (all P <.001) except for the Visuospatial/Constructional index (P >.05) showed significantly lower cognitive performance for FEDN patients than for healthy controls. Among the FEDN patients, the suicide attempters performed better than nonattempters on attention (F-1,F-121 = 5.12, P =.025), with an effect size of 0.49. The following variables were independently associated with suicide attempt as shown by multivariate regression analysis: PANSS negative symptom subscale score (Wald chi(2)(1) = 7.90 P =.005; adjusted OR = 0.807, 95% CI, 0.696-0.936) and Attention (Wald chi(2)(1) = 4.69, P =.03; adjusted OR = 0.957, 95% CI, 0.918-0.997). Conclusions: FEDN patients with schizophrenia attempt suicide more often than the general population. The suicidal patients were more likely to smoke, had lower severity of negative symptoms, and showed better attention than nonsuicidal patients. |
| WOS关键词 | QUALITY-OF-LIFE ; CIGARETTE-SMOKING ; RISK-FACTORS ; FOLLOW-UP ; PSYCHOSIS ; IDEATION ; BEHAVIOR ; NEUROCOGNITION ; METAANALYSIS ; INDIVIDUALS |
| 资助项目 | National Natural Science Foundation of China[81371477] ; Scientific and Technological Program of Suzhou[SYS201261] ; Key Diagnosis and treatment Program of Suzhou[LCZX201515] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Suzhou Key Disciplines for Psychiatry[Szxk201515] |
| WOS研究方向 | Psychology ; Psychiatry |
| 语种 | 英语 |
| 出版者 | PHYSICIANS POSTGRADUATE PRESS |
| WOS记录号 | WOS:000452890900013 |
| 资助机构 | National Natural Science Foundation of China ; Scientific and Technological Program of Suzhou ; Key Diagnosis and treatment Program of Suzhou ; Suzhou Key Medical Center for Psychiatric Diseases ; Suzhou Key Disciplines for Psychiatry |
| 源URL | [http://ir.psych.ac.cn/handle/311026/27944]  |
| 专题 | 心理研究所_健康与遗传心理学研究室 |
| 通讯作者 | Zhang, Xiang Yang |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 2.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 3.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Jiangsu, Peoples R China 4.Peking Univ, Beijing Hui Long Guan Hosp, Beijing, Peoples R China 5.Xinxiang Med Univ, Affiliated Hosp 2, Xinxiang, Henan, Peoples R China 6.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiang Yang,Du, Xiangdong,Yin, Guangzhong,et al. Prevalence and Clinical Correlates of and Cognitive Function at the Time of Suicide Attempts in First-Episode and Drug-Naive Patients With Schizophrenia[J]. JOURNAL OF CLINICAL PSYCHIATRY,2018,79(4):8. |
| APA | Zhang, Xiang Yang.,Du, Xiangdong.,Yin, Guangzhong.,Zhang, Yingyang.,Chen, Dachun.,...&Soares, Jair C..(2018).Prevalence and Clinical Correlates of and Cognitive Function at the Time of Suicide Attempts in First-Episode and Drug-Naive Patients With Schizophrenia.JOURNAL OF CLINICAL PSYCHIATRY,79(4),8. |
| MLA | Zhang, Xiang Yang,et al."Prevalence and Clinical Correlates of and Cognitive Function at the Time of Suicide Attempts in First-Episode and Drug-Naive Patients With Schizophrenia".JOURNAL OF CLINICAL PSYCHIATRY 79.4(2018):8. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。