Effects of smoking on cognition and BDNF levels in a male Chinese population: relationship with BDNF Val66Met polymorphism
文献类型:期刊论文
作者 | Xia, Haisen1; Du, Xiangdong2; Yin, Guangzhong2; Zhang, Yingyang2; Li, Xiaosi1; Cai, Junyi3; Huang, Xingbing3; Ning, Yuping3; Soares, Jair C.4; Wu, Fengchun3 |
刊名 | SCIENTIFIC REPORTS |
出版日期 | 2019-01-18 |
卷号 | 9页码:9 |
ISSN号 | 2045-2322 |
DOI | 10.1038/s41598-018-36419-8 |
产权排序 | 5 |
文献子类 | Article |
英文摘要 | Recent studies demonstrate that brain-derived neurotrophic factor (BDNF) might be associated with nicotine addiction, and circulating BDNF is a biomarker of memory and general cognitive function. Moreover, studies suggest that a functional polymorphism of the BDNF Val66Met may mediate hippocampal-dependent cognitive functions. We aimed to explore the relationships between smoking, cognitive performance and BDNF in a normal Chinese Han population. We recruited 628 male healthy subjects, inducing 322 smokers and 306 nonsmokers, and genotyped them the BDNF Val66Met polymorphism. Of these, we assessed 114 smokers and 98 nonsmokers on the repeatable battery for the assessment of neuropsychological status (RBANS), and 103 smokers and 89 nonsmokers on serum BDNF levels. Smokers scored lower than the nonsmokers on RBANS total score (p = 0.002), immediate memory (p = 0.003) and delayed memory (p = 0.021). BDNF levels among the smokers who were Val allele carriers were correlated with the degree of cognitive impairments, especially attention, as well as with the carbon monoxide concentrations. Our findings suggest that smoking is associated with cognitive impairment in a male Chinese Han population. The association between higher BDNF levels and cognitive impairment, mainly attention in smokers appears to be dependent on the BDNF Val66Met polymorphism. |
WOS关键词 | Neurotrophic Factor Bdnf ; Activity-dependent Secretion ; Factor Messenger-rna ; Val(66)Met Polymorphism ; Cigarette-smoking ; Tobacco Smoking ; Nicotine Dependence ; Human-memory ; Association ; Serum |
资助项目 | Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Science and Technology Program of Guangdong[2016A020216004] ; Science and Technology Program of Guangzhou[201704020168] ; Science and Technology Program of Guangzhou[201807010064] ; Suzhou Key Project (Psychiatry)[Szxk201515] ; Suzhou Key Diagnosis and Treatment Program[LCZX201316] ; Jiangsu Province Natural Science Fund Project[BK20151197] |
WOS研究方向 | Science & Technology - Other Topics |
语种 | 英语 |
出版者 | NATURE PUBLISHING GROUP |
WOS记录号 | WOS:000456008900015 |
源URL | [http://ir.psych.ac.cn/handle/311026/28220] |
专题 | 心理研究所_健康与遗传心理学研究室 |
通讯作者 | Wu, Fengchun; Zhang, Xiang Yang |
作者单位 | 1.Hefei Fourth Peoples Hosp, Anhui Mental Hlth Ctr, Hefei, Anhui, Peoples R China 2.Soochow Univ, Suzhou Psychiat Hosp, Affiliated Guangji Hosp, Suzhou, Jiangsu, Peoples R China 3.Guangzhou Med Univ, Affiliated Brain Hosp, Guangzhou Huiai Hosp, Guangzhou, Guangdong, Peoples R China 4.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 5.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Xia, Haisen,Du, Xiangdong,Yin, Guangzhong,et al. Effects of smoking on cognition and BDNF levels in a male Chinese population: relationship with BDNF Val66Met polymorphism[J]. SCIENTIFIC REPORTS,2019,9:9. |
APA | Xia, Haisen.,Du, Xiangdong.,Yin, Guangzhong.,Zhang, Yingyang.,Li, Xiaosi.,...&Zhang, Xiang Yang.(2019).Effects of smoking on cognition and BDNF levels in a male Chinese population: relationship with BDNF Val66Met polymorphism.SCIENTIFIC REPORTS,9,9. |
MLA | Xia, Haisen,et al."Effects of smoking on cognition and BDNF levels in a male Chinese population: relationship with BDNF Val66Met polymorphism".SCIENTIFIC REPORTS 9(2019):9. |
入库方式: OAI收割
来源:心理研究所
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