Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
文献类型:期刊论文
作者 | Huckins, Laura M.1,2,3,4; Dobbyn, Amanda1,2; Ruderfer, Douglas M.5; Hoffman, Gabriel1,4; Wang, Weiqing1,2; Pardinas, Antonio F.6; Rajagopal, Veera M.7,8,9; Als, Thomas D.7,8,9; Nguyen, Hoang T.1,2; Girdhar, Kiran1,2 |
刊名 | NATURE GENETICS |
出版日期 | 2019-04-01 |
卷号 | 51期号:4页码:659-+ |
ISSN号 | 1061-4036 |
DOI | 10.1038/s41588-019-0364-4 |
文献子类 | Article |
英文摘要 | Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression. |
WOS关键词 | ACUTE INTERMITTENT PORPHYRIA ; COGNITIVE DEFICITS ; ASSOCIATION ; MOUSE ; TRANSCRIPTOME ; CHILDHOOD ; TRAITS ; PSYCHOSIS ; DISORDER ; VARIANTS |
WOS研究方向 | Genetics & Heredity |
语种 | 英语 |
出版者 | NATURE PUBLISHING GROUP |
WOS记录号 | WOS:000462767500013 |
源URL | [http://ir.psych.ac.cn/handle/311026/28796] |
专题 | 心理研究所_健康与遗传心理学研究室 |
通讯作者 | Huckins, Laura M.; Huckins, Laura M. |
作者单位 | 1.Icahn Sch Med Mt Sinai, Pamela Sklar Div Psychiat Genom, New York, NY 10029 USA 2.Icahn Sch Med Mt Sinai, Dept Genet & Genom, New York, NY 10029 USA 3.Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA 4.Icahn Sch Med Mt Sinai, Icahn Inst Genom & Multiscale Biol, New York, NY 10029 USA 5.Vanderbilt Univ, Med Ctr, 221 Kirkland Hall, Nashville, TN 37235 USA 6.Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, S Glam, Wales 7.Aarhus Univ, Dept Biomed, Aarhus, Denmark 8.iPSYCH, Lundbeck Fdn Initiat Integrat Psychiat Res, Aarhus, Denmark 9.Aarhus Univ, Ctr Integrat Sequencing, Aarhus, Denmark 10.Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA |
推荐引用方式 GB/T 7714 | Huckins, Laura M.,Dobbyn, Amanda,Ruderfer, Douglas M.,et al. Gene expression imputation across multiple brain regions provides insights into schizophrenia risk[J]. NATURE GENETICS,2019,51(4):659-+. |
APA | Huckins, Laura M..,Dobbyn, Amanda.,Ruderfer, Douglas M..,Hoffman, Gabriel.,Wang, Weiqing.,...&Sullivan, Patrick F..(2019).Gene expression imputation across multiple brain regions provides insights into schizophrenia risk.NATURE GENETICS,51(4),659-+. |
MLA | Huckins, Laura M.,et al."Gene expression imputation across multiple brain regions provides insights into schizophrenia risk".NATURE GENETICS 51.4(2019):659-+. |
入库方式: OAI收割
来源:心理研究所
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