A Conflict Model of Reward-seeking Behavior in Male Rats
文献类型:期刊论文
作者 | Jiang, Shaofei1,2; Zhang, Yue1,2; Zheng, Xigeng1,2![]() ![]() ![]() |
刊名 | JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
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出版日期 | 2019-02-01 |
期号 | 144页码:8 |
关键词 | Retraction Issue 144 morphine withdrawal conflict inhibitory control sexual reward stress |
ISSN号 | 1940-087X |
DOI | 10.3791/59141 |
产权排序 | 1 |
文献子类 | Article |
英文摘要 | The present protocol describes a novel conflict task as a model of inhibitory control in rats. In this model, a natural rewarding stimulus (sexual stimulus) that represents a high-value reward, and the aversive stimuli (pins), are concurrently presented. The male rats have to climb or jump over the obstacle full of pins to approach and investigate the sexual partner. If the animal persists in their approaching behavior regardless of the aversive stimuli, it is considered as a maladaptive or risky reward-seeking behavior. The conflict task permits the evaluation of deficit in inhibitory control resulting from exposure to abused drug, such as morphine, or a stressful event. The main advantage of this model is that it provides a simple and quick way to discover the deficit in inhibitory control after exposure to opiate drugs or other stressful events. In addition to opiates, this behavioral model would also be useful for quickly discovering the inhibitory control deficits induced by other addictive drugs. However, the limitation is that the male rats' performance may be subject to exercising effects with repeated testing under this conflict task. In the future, one can hope that the individuals with the compulsive phenotype of reward-seeking behavior after exposure to opiates will be identified based on modifying this conflict model. |
WOS关键词 | LONG-TERM WITHDRAWAL ; ORBITOFRONTAL CORTEX ; OPIOID RECEPTORS ; NEURAL BASIS ; ADDICTION ; TASK ; IMPULSIVITY ; INHIBITION ; MECHANISMS ; DEFICITS |
WOS研究方向 | Science & Technology - Other Topics |
语种 | 英语 |
WOS记录号 | WOS:000462905000067 |
出版者 | JOURNAL OF VISUALIZED EXPERIMENTS |
源URL | [http://ir.psych.ac.cn/handle/311026/28802] ![]() |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Liu, Zhengkui; Bai, Yunjing |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Jiang, Shaofei,Zhang, Yue,Zheng, Xigeng,et al. A Conflict Model of Reward-seeking Behavior in Male Rats[J]. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS,2019(144):8. |
APA | Jiang, Shaofei,Zhang, Yue,Zheng, Xigeng,Luo, Haoshuang,Liu, Zhengkui,&Bai, Yunjing.(2019).A Conflict Model of Reward-seeking Behavior in Male Rats.JOVE-JOURNAL OF VISUALIZED EXPERIMENTS(144),8. |
MLA | Jiang, Shaofei,et al."A Conflict Model of Reward-seeking Behavior in Male Rats".JOVE-JOURNAL OF VISUALIZED EXPERIMENTS .144(2019):8. |
入库方式: OAI收割
来源:心理研究所
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