中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
A Conflict Model of Reward-seeking Behavior in Male Rats

文献类型:期刊论文

作者Jiang, Shaofei1,2; Zhang, Yue1,2; Zheng, Xigeng1,2; Luo, Haoshuang1,2; Liu, Zhengkui1,2; Bai, Yunjing1,2
刊名JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
出版日期2019-02-01
期号144页码:8
关键词Retraction Issue 144 morphine withdrawal conflict inhibitory control sexual reward stress
ISSN号1940-087X
DOI10.3791/59141
产权排序1
文献子类Article
英文摘要

The present protocol describes a novel conflict task as a model of inhibitory control in rats. In this model, a natural rewarding stimulus (sexual stimulus) that represents a high-value reward, and the aversive stimuli (pins), are concurrently presented. The male rats have to climb or jump over the obstacle full of pins to approach and investigate the sexual partner. If the animal persists in their approaching behavior regardless of the aversive stimuli, it is considered as a maladaptive or risky reward-seeking behavior. The conflict task permits the evaluation of deficit in inhibitory control resulting from exposure to abused drug, such as morphine, or a stressful event. The main advantage of this model is that it provides a simple and quick way to discover the deficit in inhibitory control after exposure to opiate drugs or other stressful events. In addition to opiates, this behavioral model would also be useful for quickly discovering the inhibitory control deficits induced by other addictive drugs. However, the limitation is that the male rats' performance may be subject to exercising effects with repeated testing under this conflict task. In the future, one can hope that the individuals with the compulsive phenotype of reward-seeking behavior after exposure to opiates will be identified based on modifying this conflict model.

WOS关键词LONG-TERM WITHDRAWAL ; ORBITOFRONTAL CORTEX ; OPIOID RECEPTORS ; NEURAL BASIS ; ADDICTION ; TASK ; IMPULSIVITY ; INHIBITION ; MECHANISMS ; DEFICITS
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:000462905000067
出版者JOURNAL OF VISUALIZED EXPERIMENTS
源URL[http://ir.psych.ac.cn/handle/311026/28802]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Liu, Zhengkui; Bai, Yunjing
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Shaofei,Zhang, Yue,Zheng, Xigeng,et al. A Conflict Model of Reward-seeking Behavior in Male Rats[J]. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS,2019(144):8.
APA Jiang, Shaofei,Zhang, Yue,Zheng, Xigeng,Luo, Haoshuang,Liu, Zhengkui,&Bai, Yunjing.(2019).A Conflict Model of Reward-seeking Behavior in Male Rats.JOVE-JOURNAL OF VISUALIZED EXPERIMENTS(144),8.
MLA Jiang, Shaofei,et al."A Conflict Model of Reward-seeking Behavior in Male Rats".JOVE-JOURNAL OF VISUALIZED EXPERIMENTS .144(2019):8.

入库方式: OAI收割

来源:心理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。