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Neural Oscillations Underlying The Extinction of Conditioned Fear Memory

文献类型：期刊论文

作者Xia Wen-Ran1,2; Chen Si1,2; Wang Liang1,2,3
刊名PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
出版日期2019-03-01
卷号46期号:3页码:276-286
ISSN号1000-3282
关键词fear extinction fear memory neural oscillations neural circuits
DOI10.16476/j.pibb.2018.0251
通讯作者Wang Liang(lwang@psych.ac.cn)
英文摘要As part of the self-protection mechanism that individuals use to deal with internal and external risk factors, fear plays an important role in the survival of organisms. However, excessive fear is not only detrimental to the survival of the individual, but also easy to cause mental illness such as post-traumatic stress disorder and anxiety, which seriously affects the quality of life. Clinically, exposure therapy based on behavioral findings is often used to treat fear-related diseases, but these symptoms often recur when the patient break away from the treatment environment. Therefore, the investigation of the information processing in the neural circuits related to fear memory is essential for understanding the occurrence and development of these diseases and establishing new treatments. Numerous studies have demonstrated that the brain regions associated with the extinction of fear memory mainly include the amygdala, medial prefrontal cortex and hippocampus. In the process of fear extinction, these three brain regions show specific patterns of neural oscillations, and their activities are also synchronized, which constitute the neural basis for the successful extinction of fear memory. In the future, non-invasive brain stimulation based on oscillatory entrainment can be used to intervene the neural circuit and promote the extinction of fear memory and avoid the recurrence of fear, which provides new insights into the treatment of clinical fear-related disorders.
WOS关键词VENTROMEDIAL PREFRONTAL CORTEX ; TRANSCRANIAL MAGNETIC STIMULATION ; POSTTRAUMATIC-STRESS-DISORDER ; GABA-LIKE IMMUNOREACTIVITY ; LOW-FREQUENCY STIMULATION ; GAMMA OSCILLATIONS ; BASOLATERAL AMYGDALA ; SYNAPTIC PLASTICITY ; VENTRAL HIPPOCAMPUS ; NEURONAL CIRCUITS
资助项目Beijing Municipal Science and Technology Commission[Z171100000117014] ; National Key Research and Development Program of China[2016YFC1307200] ; Strategic Priority Research Program of Chinese Academy of Sciences[XDB32010300]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
出版者CHINESE ACAD SCIENCES, INST BIOPHYSICS
WOS记录号WOS:000462553900006
资助机构Beijing Municipal Science and Technology Commission ; National Key Research and Development Program of China ; Strategic Priority Research Program of Chinese Academy of Sciences
源URL[http://ir.psych.ac.cn/handle/311026/28829]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wang Liang
作者单位1.Chinese Acad Sci, CAS Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
3.CAS Ctr Excellence Brain Sci & Intelligence Tec, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714		 Xia Wen-Ran,Chen Si,Wang Liang. Neural Oscillations Underlying The Extinction of Conditioned Fear Memory[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2019,46(3):276-286.
APA Xia Wen-Ran,Chen Si,&Wang Liang.(2019).Neural Oscillations Underlying The Extinction of Conditioned Fear Memory.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,46(3),276-286.
MLA Xia Wen-Ran,et al."Neural Oscillations Underlying The Extinction of Conditioned Fear Memory".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 46.3(2019):276-286.

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来源：心理研究所

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