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Regional metabolic differences in rat prefrontal cortex measured with in vivo H-1-MRS correlate with regional histochemical differences

文献类型：期刊论文

作者Lei, Hao2; Zou, Yijuan2; Zhang, Hui1,2
刊名NMR IN BIOMEDICINE
出版日期2019
卷号32期号:1页码:10
ISSN号0952-3480
关键词glutamate MRS neurotransmission prefrontal cortex rat
DOI10.1002/nbm.4024
英文摘要Many neurological/psychiatric disorders are associated with metabolic abnormalities in the brain observable with in vivo proton MRS (H-1-MRS). The underlying molecular/cellular mechanisms and functional correlations of such metabolic alterations, however, are yet to be understood fully. The rodent prefrontal cortex (PFC) is comprised of multiple sub-regions with distinctive cytoarchitecture and functions, providing a good model system to study the correlations among cerebral metabolism, regional cytoarchitecture and connectivity. In this study, the metabolic profiles in two voxels containing mainly the medial PFC (mPFC) and posterior part of the cingulate cortex (pCG), respectively, were measured with single-voxel in vivo H-1-MRS in adult male rats. The levels of glutamine synthetase and glutamatergic synaptic proteins, including vesicular glutamate transporter 1, vesicular glutamate transporter 2 (VGLUT2) and post-synaptic density protein 95 (PSD95), as well as the density of astrocytes, in these two regions were also compared semi-quantitatively. It was shown that, relative to the pCG voxel, the mPFC voxel had significantly higher N-acetyl aspartate, glutamate (Glu), glutamine (Gln), Glx (Glu + Gln), myo-inositol and taurine levels. The VGLUT2/PSD95 levels and astrocyte density were also higher in the mPFC voxel than in the pCG voxel. Taken together, these results indicated that regional metabolic variations in the PFC of the adult male rat may reflect regional differences in the density of astrocytes and glutamatergic terminals associated with subcortical projections. The study provided a link between the Glu concentration measured with localized in vivo H-1-MRS and regional glutamatergic activities/connections in the rat PFC.
WOS关键词CEREBRAL GLUCOSE-UTILIZATION ; FIBRILLARY ACIDIC PROTEIN ; NEUROCHEMICAL PROFILE ; GLUTAMINE-SYNTHETASE ; ANTERIOR CINGULATE ; ENERGY-METABOLISM ; NMR-SPECTROSCOPY ; BRAIN ; GABA ; SCHIZOPHRENIA
资助项目National Natural Science Foundation of China[21790392] ; National Natural Science Foundation of China[21790390] ; K. C. Wong Educational Foundation
WOS研究方向Biophysics ; Radiology, Nuclear Medicine & Medical Imaging ; Spectroscopy
语种英语
出版者WILEY
WOS记录号WOS:000453830400012
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; K. C. Wong Educational Foundation ; K. C. Wong Educational Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; K. C. Wong Educational Foundation ; K. C. Wong Educational Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; K. C. Wong Educational Foundation ; K. C. Wong Educational Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; K. C. Wong Educational Foundation ; K. C. Wong Educational Foundation
源URL[http://ir.wipm.ac.cn/handle/112942/13478]  
专题中国科学院武汉物理与数学研究所
通讯作者Lei, Hao
作者单位1.Univ Chinese Acad Sci, Beijing, Peoples R China
2.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, Wuhan, Hubei, Peoples R China
推荐引用方式
GB/T 7714		 Lei, Hao,Zou, Yijuan,Zhang, Hui. Regional metabolic differences in rat prefrontal cortex measured with in vivo H-1-MRS correlate with regional histochemical differences[J]. NMR IN BIOMEDICINE,2019,32(1):10.
APA Lei, Hao,Zou, Yijuan,&Zhang, Hui.(2019).Regional metabolic differences in rat prefrontal cortex measured with in vivo H-1-MRS correlate with regional histochemical differences.NMR IN BIOMEDICINE,32(1),10.
MLA Lei, Hao,et al."Regional metabolic differences in rat prefrontal cortex measured with in vivo H-1-MRS correlate with regional histochemical differences".NMR IN BIOMEDICINE 32.1(2019):10.

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来源：武汉物理与数学研究所

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