Nanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between beta-sheets
文献类型：期刊论文
| 作者 | Xu, Hai4; Lu, Jian Ren2; Yang, Jun3; Waigh, Thomas A.2; Cox, Henry2; Rogers, Sarah E.1; King, Stephen M.1; Hu, Xuzhi2; Li, Zongyi2; Wang, Dong4 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2018-11-30 |
| 卷号 | 9页码:11 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-018-07583-2 |
| 英文摘要 | Peptide self-assembly is a hierarchical process, often starting with the formation of a-helices, beta-sheets or beta-hairpins. However, how the secondary structures undergo further assembly to form higher-order architectures remains largely unexplored. The polar zipper originally proposed by Perutz is formed between neighboring beta-strands of poly-glutamine via their side-chain hydrogen bonding and helps to stabilize the sheet. By rational design of short amphiphilic peptides and their self-assembly, here we demonstrate the formation of polar zippers between neighboring beta-sheets rather than between beta-strands within a sheet, which in turn intermesh the beta-sheets into wide and flat ribbons. Such a super-secondary structural template based on well-defined hydrogen bonds could offer an agile route for the construction of distinctive nanostructures and nanomaterials beyond beta-sheets. |
| WOS关键词 | AMYLOID FIBRILS ; AMINO-ACIDS ; NANOSTRUCTURES ; POLYMORPHISM ; AMPHIPHILES ; HANDEDNESS ; NANOTUBES ; HYDROGELS ; MODEL ; NMR |
| 资助项目 | National Natural Science Foundation of China[21673293] ; National Natural Science Foundation of China[21573287] ; National Natural Science Foundation of China[21425523] ; UK Engineering and Physical Science Research Council (EPSRC) ; Innovate UK[EP/F062966/1] ; Innovate UK[KTP008143] ; NSF[DMR-0520547] ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project[654000] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000451742700023 |
| 出版者 | NATURE PUBLISHING GROUP |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; UK Engineering and Physical Science Research Council (EPSRC) ; UK Engineering and Physical Science Research Council (EPSRC) ; Innovate UK ; Innovate UK ; NSF ; NSF ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; UK Engineering and Physical Science Research Council (EPSRC) ; UK Engineering and Physical Science Research Council (EPSRC) ; Innovate UK ; Innovate UK ; NSF ; NSF ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; UK Engineering and Physical Science Research Council (EPSRC) ; UK Engineering and Physical Science Research Council (EPSRC) ; Innovate UK ; Innovate UK ; NSF ; NSF ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; UK Engineering and Physical Science Research Council (EPSRC) ; UK Engineering and Physical Science Research Council (EPSRC) ; Innovate UK ; Innovate UK ; NSF ; NSF ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project ; European Union's Horizon 2020 research and innovation programme under the SINE2020 project |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/13545]  |
| 专题 | 中国科学院武汉物理与数学研究所 |
| 通讯作者 | Xu, Hai; Lu, Jian Ren; Wang, Jiqian |
| 作者单位 | 1.STFC Rutherford Appleton Lab, ISIS Pulsed Neutron Source, Didcot OX11 0QX, Oxon, England 2.Univ Manchester, Sch Phys & Astron, Biol Phys Grp, Manchester M13 9PL, Lancs, England 3.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst,Natl Ctr Magne, Wuhan 430071, Hubei, Peoples R China 4.China Univ Petr East China, Coll Chem Engn, Ctr Bioengn & Biotechnol, 66 Changjiang West Rd, Qingdao 266580, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Hai,Lu, Jian Ren,Yang, Jun,et al. Nanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between beta-sheets[J]. NATURE COMMUNICATIONS,2018,9:11. |
| APA | Xu, Hai.,Lu, Jian Ren.,Yang, Jun.,Waigh, Thomas A..,Cox, Henry.,...&Wang, Meng.(2018).Nanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between beta-sheets.NATURE COMMUNICATIONS,9,11. |
| MLA | Xu, Hai,et al."Nanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between beta-sheets".NATURE COMMUNICATIONS 9(2018):11. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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