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Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin nanoparticle

文献类型：期刊论文

作者Du, Yang1,2,3; Fan, Kelong4; Zhang, Hejun5; Li, Li1; Wang, Peixia3,4; He, Jiuyang3,4; Ding, Shigang5; Yan, Xiyun3,4; Tian, Jie1,2,3
刊名NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
出版日期2018-10-01
卷号14期号:7页码:2259-2270
ISSN号1549-9634
关键词Early gastric cancer Confocal laser endomicroscopy Human H-ferritin Molecular imaging Fluorescently labeled nanoprobe
DOI10.1016/j.nano.2018.07.007
通讯作者Ding, Shigang(dingshigang222@163.com) ; Yan, Xiyun(yanxy@sun5.ibp.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要Optical imaging technologies improve clinical diagnostic accuracy of early gastric cancer (EGC). However, there was a lack of imaging agents exhibiting molecular specificity for EGCs. Here, we employed the dye labeled human heavy-chain ferritin (HFn) as imaging nanoprobe, which recognizes tumor biomarker transferrin receptor 1 (TfR1), to enable specific EGC imaging using confocal laser endomicroscopy (CLE). TfR1 expression was initially examined in vitro in gastric tumor cells and in vivo through whole-body fluorescence and CLE imaging in tumor-bearing mice. Subsequently, dye labeled HFn was topically applied to resected human tissues for EGC detection. CLE analysis of TfR1-targeted fluorescence imaging allowed distinction of neoplastic from non-neoplastic tissues (P < 0.0001), and TfR1 expression level was found to correlate with EGC differentiation degrees (P < 0.0001). Notably, the CLE evaluation correlated well with the immunohistochemical findings (kappa-coefficient: 0.8023). Our HFn-nanoprobe-based CLE increases the accuracy of EGC detection and enables visualization of tumor margins and endoscopic resection. (c) 2018 Elsevier Inc. All rights reserved.
WOS关键词IN-VIVO ; CONFOCAL ENDOMICROSCOPY ; PHOTODYNAMIC THERAPY ; DRUG-DELIVERY ; RECEPTOR ; NANOCAGES ; TUMORS
资助项目Ministry of Science and Technology of China[2016YFA0201404] ; Ministry of Science and Technology of China[2017YFA0205200] ; National Natural Science Foundation of China[81470083] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81571810] ; National Natural Science Foundation of China[61231004] ; National Natural Science Foundation of China[81201186] ; National Natural Science Foundation of China[31530026] ; National Natural Science Foundation of China[81671810] ; Research and Development Program of China (973)[2015CB755500] ; Young Elite Scientist Sponsorship Program by CAST[2015QNRC001] ; Strategic Priority Research Program from Chinese Academy of Sciences[XDB02060010] ; Strategic Priority Research Program from Chinese Academy of Sciences[XDA09030306] ; Key Research Program of Frontier Sciences, CAS[QYZDB-SSW-SMC013]
WOS研究方向Science & Technology - Other Topics ; Research & Experimental Medicine
语种英语
出版者ELSEVIER SCIENCE BV
WOS记录号WOS:000446496900026
资助机构Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Research and Development Program of China (973) ; Young Elite Scientist Sponsorship Program by CAST ; Strategic Priority Research Program from Chinese Academy of Sciences ; Key Research Program of Frontier Sciences, CAS
源URL[http://ir.ia.ac.cn/handle/173211/23046]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Ding, Shigang; Yan, Xiyun; Tian, Jie
作者单位1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China
2.Beijing Key Lab Mol Imaging, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Biophys, Key Lab Prot & Peptide Pharmaceut, Beijing, Peoples R China
5.Peking Univ, Hosp 3, Beijing Key Lab Helicobacter Pylori Infect & Uppe, Dept Gastroenterol, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Du, Yang,Fan, Kelong,Zhang, Hejun,et al. Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin nanoparticle[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2018,14(7):2259-2270.
APA Du, Yang.,Fan, Kelong.,Zhang, Hejun.,Li, Li.,Wang, Peixia.,...&Tian, Jie.(2018).Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin nanoparticle.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,14(7),2259-2270.
MLA Du, Yang,et al."Endoscopic molecular imaging of early gastric cancer using fluorescently labeled human H-ferritin nanoparticle".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 14.7(2018):2259-2270.

入库方式： OAI收割

来源：自动化研究所

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