Glioma-targeted imaging and therapy by Y1 receptors ligands stabilized nanomicelles across the blood brain barrier
文献类型:期刊论文
作者 | Li Juan; Du Yang; Jiang zhengqi; Tian Yuchen; Qiu Nianxiang; Wang yinjie; Muhammad Zubair lqbal; Hu Menying; Zou Ruifen; Luo Lijia |
刊名 | Nanoscale |
出版日期 | 2018-03-29 |
卷号 | 10期号:13页码:5845-5851 |
关键词 | 无 |
英文摘要 | Due to the molecular and cellular heterogeneity of glioma, discovery of novel targeted sites and ligands for glioma imaging and therapy remains challenging. Neuropeptide Y (NPY) Y1 receptors (Y1Rs) are highly over expressed in various brain tumors including glioma, and can serve as potential targeting sites for glioma imaging and therapy. Here, we show by in vivo fluorescent imaging that a highly selective Y1R ligand, [Asn6,Pro34] NPY (AP-NPY), facilitated circumvention of the blood brain barrier (BBB) by nanomicelles specifically targeting glioma. Modification with AP-NPY stabilized doxorubicin-loaded nanomicelles in the normal physiological state and promoted drug release in the acidic tumor micro-environment. Furthermore, targeted delivery of AP-NPY nanomicelles improved the therapeutic efficacy of doxorubicin for glioma, producing a prolonged survival rate. These results suggest that Y1R is a novel targeted receptor, and its selective ligand AP-NPY improves BBB permeability and glioma targeting. Our study paves the way for developing a novel delivery system for diagnosis and treatment of glioma in which Y1Rs are over expressed. |
语种 | 英语 |
源URL | [http://ir.ia.ac.cn/handle/173211/23183] |
专题 | 自动化研究所_中国科学院分子影像重点实验室 |
通讯作者 | Tian Jie; Wu aiguo |
推荐引用方式 GB/T 7714 | Li Juan,Du Yang,Jiang zhengqi,et al. Glioma-targeted imaging and therapy by Y1 receptors ligands stabilized nanomicelles across the blood brain barrier[J]. Nanoscale,2018,10(13):5845-5851. |
APA | Li Juan.,Du Yang.,Jiang zhengqi.,Tian Yuchen.,Qiu Nianxiang.,...&Wu aiguo.(2018).Glioma-targeted imaging and therapy by Y1 receptors ligands stabilized nanomicelles across the blood brain barrier.Nanoscale,10(13),5845-5851. |
MLA | Li Juan,et al."Glioma-targeted imaging and therapy by Y1 receptors ligands stabilized nanomicelles across the blood brain barrier".Nanoscale 10.13(2018):5845-5851. |
入库方式: OAI收割
来源:自动化研究所
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