中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Glioma-targeted imaging and therapy by Y1 receptors ligands stabilized nanomicelles across the blood brain barrier

文献类型:期刊论文

作者Li Juan; Du Yang; Jiang zhengqi; Tian Yuchen; Qiu Nianxiang; Wang yinjie; Muhammad Zubair lqbal; Hu Menying; Zou Ruifen; Luo Lijia
刊名Nanoscale
出版日期2018-03-29
卷号10期号:13页码:5845-5851
关键词
英文摘要

Due to the molecular and cellular heterogeneity of glioma, discov­ery of novel targeted sites and ligands for glioma imaging and therapy remains challenging. Neuropeptide Y (NPY) Y1 receptors (Y1Rs) are highly over expressed in various brain tumors including glioma, and can serve as potential targeting sites for glioma imaging and therapy. Here, we show by in vivo uorescent imaging that a highly selective Y1R ligand, [Asn6,Pro34] NPY (AP-NPY), facilitated circumvention of the blood brain barrier (BBB) by nano­micelles specically targeting glioma. Modication with AP-NPY stabilized doxorubicin-loaded nanomicelles in the normal physio­logical state and promoted drug release in the acidic tumor micro-environment. Furthermore, targeted delivery of AP-NPY nano­micelles improved the therapeutic ecacy of doxorubicin for glioma, producing a prolonged survival rate. These results suggest that Y1R is a novel targeted receptor, and its selective ligand AP-NPY improves BBB permeability and glioma targeting. Our study paves the way for developing a novel delivery system for diagnosis and treatment of glioma in which Y1Rs are over expressed.

语种英语
源URL[http://ir.ia.ac.cn/handle/173211/23183]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Tian Jie; Wu aiguo
推荐引用方式
GB/T 7714
Li Juan,Du Yang,Jiang zhengqi,et al. Glioma-targeted imaging and therapy by Y1 receptors ligands stabilized nanomicelles across the blood brain barrier[J]. Nanoscale,2018,10(13):5845-5851.
APA Li Juan.,Du Yang.,Jiang zhengqi.,Tian Yuchen.,Qiu Nianxiang.,...&Wu aiguo.(2018).Glioma-targeted imaging and therapy by Y1 receptors ligands stabilized nanomicelles across the blood brain barrier.Nanoscale,10(13),5845-5851.
MLA Li Juan,et al."Glioma-targeted imaging and therapy by Y1 receptors ligands stabilized nanomicelles across the blood brain barrier".Nanoscale 10.13(2018):5845-5851.

入库方式: OAI收割

来源:自动化研究所

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