A protective role of Heme-regulated eIF2 alpha kinase in cadmium-induced liver and kidney injuries
文献类型：期刊论文
| 作者 | Xu, Ming; Wang, Zhe; Zhang, Shuping; Wang, Lixin; Liu, Sijin; Cui, Jiansheng; Yuan, Lin |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2017 |
| 卷号 | 185期号:0页码:284-289 |
| 关键词 | Cadmium Hri Tissue Injury Monocyte Neutrophil |
| 英文摘要 | A number of studies have reported that cadmium (Cd) can incur liver and kidney injuries. The recruitment and activation of leukocytes have been demonstrated to be involved in Cd-induced biological effects. Ironically, activated leukocytes and secreted cytokines are also reported to be required for the later recovery of the damaged tissues. Yet, the mechanisms driving the production of leukocytes have not been fully elucidated. Heme-regulated elF2 alpha kinase (HRI) is essential for translational regulation and stressed erythropoiesis in iron deficiency. Meanwhile, HRI is important in the maturation and function of macrophages, indicating that HRI might be indispensable for the development and function of other myeloid lineages. Apart from macrophages, whether HRI regulates the production of leukocytes and further affects Cd-induced tissue injuries is still elusive. In this study, we aimed to elucidate the role of HRI in liver and kidney injuries and the associated mechanisms upon Cd-exposure. We found that Cd-exposed mice showed impaired production of leukocytes and developed morphological disorders in liver and kidney. Furthermore, Hri null mice exhibited a reduced number of monocytes and neutrophils and compromised cytokine production, relative to wild-type mice. Absence of Hri also exacerbated the impairments of liver and kidney upon Cd treatment. Together, these results highlighted a crucial role of HRI in protecting liver and kidney against Cd-induced injuries through inducing the development of monocytes and neutrophils. Our results further extended the understanding of HRI on the regulation of non-erythroid lineages and might provide new aspects for preventing and treating Cd-induced detrimental effects. (C) 2017 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39237]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Xu, Ming,Wang, Zhe,Zhang, Shuping,et al. A protective role of Heme-regulated eIF2 alpha kinase in cadmium-induced liver and kidney injuries[J]. CHEMOSPHERE,2017,185(0):284-289. |
| APA | Xu, Ming.,Wang, Zhe.,Zhang, Shuping.,Wang, Lixin.,Liu, Sijin.,...&Yuan, Lin.(2017).A protective role of Heme-regulated eIF2 alpha kinase in cadmium-induced liver and kidney injuries.CHEMOSPHERE,185(0),284-289. |
| MLA | Xu, Ming,et al."A protective role of Heme-regulated eIF2 alpha kinase in cadmium-induced liver and kidney injuries".CHEMOSPHERE 185.0(2017):284-289. |
入库方式： OAI收割
来源：生态环境研究中心
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