Determining the Cytotoxicity of Rare Earth Element Nanoparticles in Macrophages and the Involvement of Membrane Damage
文献类型：期刊论文
| 作者 | Shi, Jianbo; He, Bin; Zhou, Qunfang; Jiang, Guibin; Song, Maoyong; Zhang, Bin; Liu, Sijin; Qu, Guangbo; Gao, Jie; Li, Ruibin |
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2017-06-06 |
| 卷号 | 51期号:23页码:13938-13948 |
| 英文摘要 | Rare earthelement nanomaterials (REE NPs) hold considerable promise, with high availability and potential applications as superconductors, imaging agents, glass additives, fertilizers additives and feed additives. These results in potential REE NP exposure to humans and the environment through different routes and adverse effects induced by biological application of these materials are becoming an increasing concern. This study investigates the cytotoxicity of REE NPs: nLa(2)O(3), nEu(2)O(3), nDy(2)O(3) and nYb(2)O(3) from 2.5 to 80 mu g/mL, in macrophages. A significant difference was observed in the extent of cytotoxicity induced in macrophages by differential REE NPs. The high atomic number materials (i.e., nYb(2)O(3)) tending to be no toxic whereas low-atomic number materials (nLa(2)O(3) and nEu(2)O(3) and nDy(2)O(3)) induced 75.1%, 53.6% and 20.7% dead cells. With nLa(2)O(3) as the representative material, we demonstrated that nLa(2)O(3) induced cellular membrane permeabilization, through the sequestration of phosphates from membrane. The further mechanistic investigation established that membrane damage induced intracellular calcium increased to 3.0- to 7.3-fold compared to control cells. This caused the sustained overload of mitochondrial calcium by approximately 2.4-fold, which regulated cell necrosis. In addition, the injury of cellular membrane led to the release of cathepsins into cytosol which also contributed to cell death. This. detailed investigation of signaling pathways driving REE NP-induced toxicity to macrophages is essential for better understanding of their potential health risks to humans and the environment. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39290]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Shi, Jianbo,He, Bin,Zhou, Qunfang,et al. Determining the Cytotoxicity of Rare Earth Element Nanoparticles in Macrophages and the Involvement of Membrane Damage[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2017,51(23):13938-13948. |
| APA | Shi, Jianbo.,He, Bin.,Zhou, Qunfang.,Jiang, Guibin.,Song, Maoyong.,...&Hu, Ligang.(2017).Determining the Cytotoxicity of Rare Earth Element Nanoparticles in Macrophages and the Involvement of Membrane Damage.ENVIRONMENTAL SCIENCE & TECHNOLOGY,51(23),13938-13948. |
| MLA | Shi, Jianbo,et al."Determining the Cytotoxicity of Rare Earth Element Nanoparticles in Macrophages and the Involvement of Membrane Damage".ENVIRONMENTAL SCIENCE & TECHNOLOGY 51.23(2017):13938-13948. |
入库方式： OAI收割
来源：生态环境研究中心
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