Differential expression of ST6GAL1 in the tumor progression of colorectal cancer
文献类型：期刊论文
| 作者 | Zou, Xia; Zhang, Sen; Lu, Jishun; Xu, Zhijue; Sun, Xue; Xu, Yingjiao; Shan, Aidong; Lu, Jiaoyang; Yan, Xialin; Cui, Yalu |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2017-07-01 |
| 卷号 | 486期号:4页码:1090-1096 |
| 关键词 | Metabolic Labeling Sialylation St6gal1 Colorectal Cancer |
| 英文摘要 | Elevated expression of beta-galactoside alpha 2,6-sialyltranferase 1 (ST6GAL1) has been observed in colorectal cancer (CRC) and demonstrated to be important for its tumorigenesis. Here, we found that ST6GAL1 expression was significantly higher in non-metastatic tumors (stage I and II) than that in metastatic tumors (stage III and IV) using 62 pair-matched tumor/normal tissues. To elucidate the molecular mechanisms of how ST6GAL1 affected the CRC progression, we performed a global identification of the substrates of ST6GAL1 in the colon adenocarcinoma cell line SW480. A total of 318 membrane proteins were identified differentially affected by ST6GAL1 overexpression using metabolic labeling and proteomic analysis. Subsequent bioinformatic analysis revealed a list of potential substrates that might mediate the different functions of ST6GAL1 in CRC including cell movement, cell death and survival. Taken together, these results indicate a dynamic change in the expression of ST6GAL1 during the CRC progression and provide a list of sialylated proteins potentially relevant to the different functions of ST6GAL1 in CRC. (C) 2017 Elsevier Inc. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39294]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zou, Xia,Zhang, Sen,Lu, Jishun,et al. Differential expression of ST6GAL1 in the tumor progression of colorectal cancer[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017,486(4):1090-1096. |
| APA | Zou, Xia.,Zhang, Sen.,Lu, Jishun.,Xu, Zhijue.,Sun, Xue.,...&Zhang, Yan.(2017).Differential expression of ST6GAL1 in the tumor progression of colorectal cancer.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,486(4),1090-1096. |
| MLA | Zou, Xia,et al."Differential expression of ST6GAL1 in the tumor progression of colorectal cancer".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 486.4(2017):1090-1096. |
入库方式： OAI收割
来源：生态环境研究中心
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