Distinct toxicological characteristics and mechanisms of Hg2+ and MeHg in Tetrahymena under low concentration exposure
文献类型：期刊论文
| 作者 | Hu, Li-gang; Cai, Yong; Liu, Cheng-bin; Qu, Guang-bo; Cao, Meng-xi; Jiang, Gui-bin; Liang, Yong; Shi, Jian-bo |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2017-07-18 |
| 卷号 | 193期号:0页码:152-159 |
| 关键词 | Mercury Tetrahymena Cell Membrane Permeability Reactive Oxygen Species Mitochondrial Membrane Potential |
| 英文摘要 | Inorganic divalent mercury complexes (Hg2+) and monomethylmercury complexes (MeHg) are the main mercury species in aquatic systems and their toxicity to aquatic organisms is of great concern. Tetrahymena is a type of unicellular eukaryotic protozoa located at the bottom of food chain that plays a fundamental role in the biomagnification of mercury. In this work, the dynamic accumulation properties, toxicological characteristics and mechanisms of Hg2+ and MeHg in five Tetrahymena species were evaluated in detail. The results showed that both Hg2+ and MeHg were ingested and exhibited inhibitory effects on the proliferation or survival of Tetrahymena species. However, the ingestion rate of MeHg was significantly higher than that of Hg2+. The mechanisms responsible for the toxicity of MeHg and Hg2+ were different, although both chemicals altered mitochondrial membrane potential (MMP). MeHg disrupted the integrity of membranes while Hg2+ had detrimental effects on Tetrahymena as a result of the increased generation of reactive oxygen species (ROS). In addition, the five Tetrahymena species showed different capacities in accumulating Hg2+ and MeHg, with T. corlissi exhibiting the highest accumulations. The study also found significant growth-promoting effect on T. corlissi under low concentration exposure (0.003 and 0.01 mu g Hg/mL (15 and 50 nM)), suggesting different effect and mechanism that should be more closely examined when assessing the bioaccumulation and toxicity of mercury in aquatic ecosystems. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39298]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Hu, Li-gang,Cai, Yong,Liu, Cheng-bin,et al. Distinct toxicological characteristics and mechanisms of Hg2+ and MeHg in Tetrahymena under low concentration exposure[J]. AQUATIC TOXICOLOGY,2017,193(0):152-159. |
| APA | Hu, Li-gang.,Cai, Yong.,Liu, Cheng-bin.,Qu, Guang-bo.,Cao, Meng-xi.,...&Shi, Jian-bo.(2017).Distinct toxicological characteristics and mechanisms of Hg2+ and MeHg in Tetrahymena under low concentration exposure.AQUATIC TOXICOLOGY,193(0),152-159. |
| MLA | Hu, Li-gang,et al."Distinct toxicological characteristics and mechanisms of Hg2+ and MeHg in Tetrahymena under low concentration exposure".AQUATIC TOXICOLOGY 193.0(2017):152-159. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。