Efficient One-Pot Synthesis of 2,4-Disubstituted Thiazoles and Dimeric Thiazoles Directly from Acyl Chlorides and -Azido Disulfides
文献类型：期刊论文
| 作者 | Fan, Xinyuan; Liu, Yi; Li, Zhi; Xie, Yichuan; He, Peng; Qiao, Junfei; Du, Yuguo |
| 刊名 | SYNTHESIS-STUTTGART
 |
| 出版日期 | 2017-08-01 |
| 卷号 | 49期号:21页码:4876-4886 |
| 关键词 | One-pot Reaction Dimeric Thiazole 2 Acid Chloride 4-disubstituted Thiazole Smart |
| 英文摘要 | A simple and effective one-pot cascade procedure to provide 2,4-disubstituted thiazoles and symmetrical dimeric thiazoles directly from commercially available acid chlorides and -azido disulfides in moderate to high yields is described. This cascade transformation consists of disulfide cleavage, thiocarbonylation, phosphine-promoted intramolecular Staudinger/aza-Wittig reaction and dehydrogenation to form the corresponding thiazoles. The application of our methodology is demonstrated by the concise two-step synthesis of anticancer agent SMART and its O-linked dimer in 64% and 46% overall yields, respectively. This directed cascade reaction could be easily handled and scaled up under mild conditions, enabling the construction of focused thiazole derivatives for further pharmacological evaluation. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39302]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Fan, Xinyuan,Liu, Yi,Li, Zhi,et al. Efficient One-Pot Synthesis of 2,4-Disubstituted Thiazoles and Dimeric Thiazoles Directly from Acyl Chlorides and -Azido Disulfides[J]. SYNTHESIS-STUTTGART,2017,49(21):4876-4886. |
| APA | Fan, Xinyuan.,Liu, Yi.,Li, Zhi.,Xie, Yichuan.,He, Peng.,...&Du, Yuguo.(2017).Efficient One-Pot Synthesis of 2,4-Disubstituted Thiazoles and Dimeric Thiazoles Directly from Acyl Chlorides and -Azido Disulfides.SYNTHESIS-STUTTGART,49(21),4876-4886. |
| MLA | Fan, Xinyuan,et al."Efficient One-Pot Synthesis of 2,4-Disubstituted Thiazoles and Dimeric Thiazoles Directly from Acyl Chlorides and -Azido Disulfides".SYNTHESIS-STUTTGART 49.21(2017):4876-4886. |
入库方式： OAI收割
来源：生态环境研究中心
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