Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure
文献类型：期刊论文
| 作者 | Zhang, Songyan; Chen, Yangsheng; Xu, Li; Xie, Heidi Q. H.; Xu, Tuan; Fu, Hualing; Sha, Rui; Xia, Yingjie; Zhao, Bin |
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES
 |
| 出版日期 | 2017-10-28 |
| 卷号 | 62期号:0页码:92-99 |
| 关键词 | Tcdd Long-term Exposure Neurotoxicity Microarray Neuroinflammation |
| 英文摘要 | Several cohort studies have reported that dioxin and dioxin-like polychlorinated biphenyls might impair the nervous system and lead to neurological or neurodegenerative diseases in the elder people, but there is limited research on the involved mechanism. By using microarray analysis, we figured out the differentially expressed genes between brain samples from SD rats after low-dose (0.1 mu g/(kg.bw)) dioxin exposure for six months and controls. To investigate the function changes in the course of dioxin exposure, Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed on the differentially expressed genes. And the changes of several picked genes have been verified by real-time PCR. A total of 145 up-regulated and 64 down-regulated genes were identified. The metabolic processes, interleukin-1 secretion and production were significantly associated with the differentially expressed genes. And the genes regulated by dioxin also clustered to cholinergic synapse and long-term potentiation. Candidate biomarker genes such as egr1, gad2, gabrb3, abca1, ccr5 and pycard may be toxicological targets for dioxin. Furthermore, synaptic plasticity and neuro-immune system may be two principal affected areas by dioxin. (C) 2017 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39332]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, Songyan,Chen, Yangsheng,Xu, Li,et al. Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2017,62(0):92-99. |
| APA | Zhang, Songyan.,Chen, Yangsheng.,Xu, Li.,Xie, Heidi Q. H..,Xu, Tuan.,...&Zhao, Bin.(2017).Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure.JOURNAL OF ENVIRONMENTAL SCIENCES,62(0),92-99. |
| MLA | Zhang, Songyan,et al."Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure".JOURNAL OF ENVIRONMENTAL SCIENCES 62.0(2017):92-99. |
入库方式： OAI收割
来源：生态环境研究中心
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