Low concentrations of bisphenol A promote human ovarian cancer cell proliferation and glycolysis-based metabolism through the estrogen receptor-alpha pathway
文献类型：期刊论文
| 作者 | Shi, Xiao-Yu; Gao, Hui; Wang, Zhe; Liu, Liyu; Feng, Li-Min; Li, Nan; Liu, Sijin |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2017-12-19 |
| 卷号 | 185期号:0页码:361-367 |
| 关键词 | Bisphenol a Ovarian Cancer Energy Metabolism Er Alpha |
| 英文摘要 | Bisphenol A (BPA) is one of the most prevalent chemicals in many products used on a daily basis, making human exposure to it incredibly pervasive and raising concerns about its health consequences. One area of research focus has been the role of BPA exposure in promoting the development of ovarian cancer; however, the doses used in most of previous studies are relatively high and most likely exceed physiologically relevant levels. At the same time, few studies have described potential mechanisms underlying the link between BPA and increased cancer risk. To address these concerns we investigated the mechanism(s) by which low concentrations of BPA promote proliferation and energy metabolism in the human ovarian cancer cell line OVCAR-3. We found that even sub-toxic BPA concentrations not only drove increased OVCAR-3 cell proliferation but also promoted glycolysis-based metabolism, as evidenced by elevated cell viability, accelerated cell proliferation, increased levels of intracellular ATP, lactate, and pyruvic acid. Importantly, all of these effects were estrogen receptor a (ERa) dependent, as siRNA-mediated ERa silencing decreased BPA-induced proliferation, pinpointing the crucial role of ERa-conducted signaling in BPA-induced biological effects. Together, our findings revealed a new mechanism through which BPA promoted cell proliferation by reinforcing glycolysis-based energy production dependent on ER signaling. This study would thus open a new path to understand BPA-induced biological effects on tumor cells. Copyright (C) 2017 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39353]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Shi, Xiao-Yu,Gao, Hui,Wang, Zhe,et al. Low concentrations of bisphenol A promote human ovarian cancer cell proliferation and glycolysis-based metabolism through the estrogen receptor-alpha pathway[J]. CHEMOSPHERE,2017,185(0):361-367. |
| APA | Shi, Xiao-Yu.,Gao, Hui.,Wang, Zhe.,Liu, Liyu.,Feng, Li-Min.,...&Liu, Sijin.(2017).Low concentrations of bisphenol A promote human ovarian cancer cell proliferation and glycolysis-based metabolism through the estrogen receptor-alpha pathway.CHEMOSPHERE,185(0),361-367. |
| MLA | Shi, Xiao-Yu,et al."Low concentrations of bisphenol A promote human ovarian cancer cell proliferation and glycolysis-based metabolism through the estrogen receptor-alpha pathway".CHEMOSPHERE 185.0(2017):361-367. |
入库方式： OAI收割
来源：生态环境研究中心
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