Mesoporous carbon nanomaterials induced pulmonary surfactant inhibition, cytotoxicity, inflammation and lung fibrosis
文献类型：期刊论文
| 作者 | Chen, Yunan; Yang, Yi; Xu, Bolong; Wang, Shunhao; Li, Bin; Ma, Juan; Gao, Jie; Zuo, Yi Y.; Liu, Sijin |
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES
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| 出版日期 | 2017-08-01 |
| 卷号 | 62期号:0页码:100-114 |
| 关键词 | Mesoporous Carbon Nanomaterials Environmental Exposure Pulmonary Surfactant Inflammation Fibrosis |
| 英文摘要 | Environmental exposure and health risk upon engineered nanomaterials are increasingly concerned. The family of mesoporous carbon nanomaterials (MCNs) is a rising star in nanotechnology for multidisciplinary research with versatile applications in electronics, energy and gas storage, and biomedicine. Meanwhile, there is mounting concern on their environmental health risks due to the growing production and usage of MCNs. The lung is the primary site for particle invasion under environmental exposure to nanomaterials. Here, we studied the comprehensive toxicological profile of MCNs in the lung under the scenario of moderate environmental exposure. It was found that at a low concentration of 10 mu g/mL MCNs induced biophysical inhibition of natural pulmonary surfactant. Moreover, MCNs at similar concentrations reduced viability of J774A.1 macrophages and lung epithelial A549 cells. Incubating with nature pulmonary surfactant effectively reduced the cytotoxicity of MCNs. Regarding the pro-inflammatory responses, MCNs activated macrophages in vitro, and stimulated lung inflammation in mice after inhalation exposure, associated with lung fibrosis. Moreover, we found that the size of MCNs played a significant role in regulating cytotoxicity and pro-inflammatory potential of this nanomaterial. In general, larger MCNs induced more pronounced cytotoxic and pro-inflammatory effects than their smaller counterparts. Our results provided valuable information on the toxicological profile and environmental health risks of MCNs, and suggested that fine-tuning the size of MCNs could be a practical precautionary design strategy to increase safety and biocompatibility of this nanomaterial. (C) 2017 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39360]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen, Yunan,Yang, Yi,Xu, Bolong,et al. Mesoporous carbon nanomaterials induced pulmonary surfactant inhibition, cytotoxicity, inflammation and lung fibrosis[J]. JOURNAL OF ENVIRONMENTAL SCIENCES,2017,62(0):100-114. |
| APA | Chen, Yunan.,Yang, Yi.,Xu, Bolong.,Wang, Shunhao.,Li, Bin.,...&Liu, Sijin.(2017).Mesoporous carbon nanomaterials induced pulmonary surfactant inhibition, cytotoxicity, inflammation and lung fibrosis.JOURNAL OF ENVIRONMENTAL SCIENCES,62(0),100-114. |
| MLA | Chen, Yunan,et al."Mesoporous carbon nanomaterials induced pulmonary surfactant inhibition, cytotoxicity, inflammation and lung fibrosis".JOURNAL OF ENVIRONMENTAL SCIENCES 62.0(2017):100-114. |
入库方式： OAI收割
来源：生态环境研究中心
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