NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression
文献类型：期刊论文
| 作者 | Dang, Baoyen; Faiola, Francesco; Yin, Nuoya; Fidalgo, Miguel; Huang, Xin; Saunders, Arven; Ding, Junjun; Guallar, Diana; Wang, Jianlong |
| 刊名 | STEM CELL REPORTS
 |
| 出版日期 | 2017-12-01 |
| 卷号 | 9期号:3页码:913-926 |
| 英文摘要 | Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) is a long and inefficient process. A thorough understanding of the molecular mechanisms underlying reprogramming is paramount for efficient generation and safe application of iPSCs in medicine. While intensive efforts have been devoted to identifying reprogramming facilitators and barriers, a full repertoire of such factors, as well as their mechanistic actions, is poorly defined. Here, we report that NAC1, a pluripotency-associated factor and NANOG partner, is required for establishment of pluripotency during reprogramming. Mechanistically, NAC1 is essential for proper expression of E-cadherin by a dual regulatory mechanism: it facilitates NANOGbinding to the E-cadherin promoter and fine-tunes its expression; most importantly, it downregulates the E-cadherin repressor ZEB1 directly via transcriptional repression and indirectly via post-transcriptional activation of the miR-200 miRNAs. Our study thus uncovers a previously unappreciated role for the pluripotency regulator NAC1 in promoting efficient somatic cell reprogramming. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39367]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Dang, Baoyen,Faiola, Francesco,Yin, Nuoya,et al. NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression[J]. STEM CELL REPORTS,2017,9(3):913-926. |
| APA | Dang, Baoyen.,Faiola, Francesco.,Yin, Nuoya.,Fidalgo, Miguel.,Huang, Xin.,...&Wang, Jianlong.(2017).NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression.STEM CELL REPORTS,9(3),913-926. |
| MLA | Dang, Baoyen,et al."NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression".STEM CELL REPORTS 9.3(2017):913-926. |
入库方式： OAI收割
来源：生态环境研究中心
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