Product identification and the mechanisms involved in the transformation of cefazolin by birnessite (delta-MnO2)
文献类型：期刊论文
| 作者 | Li, Liping; Wei, Dongbin; Wei, Guohua; Du, Yuguo |
| 刊名 | CHEMICAL ENGINEERING JOURNAL
 |
| 出版日期 | 2017 |
| 卷号 | 320期号:0页码:116-123 |
| 关键词 | Cefazolin Manganese Dioxide Beta-lactam Antibiotics Transformation Products Oxidation Mechanism |
| 英文摘要 | Cefazolin, a widely used cephalosporin antibiotic in human therapy, was the target in this study. Manganese dioxide, which is abundant in soils and sediments, is one of the most important natural oxidants and catalysts. To better understand the fate of cephalosporin antibiotics in natural soils and sediments, the transformation of cefazolin with manganese dioxide (delta-MnO2) was investigated. Four major transformation products formed via the oxidation of thioether and olefin, hydrolysis and acid-catalyzed decarboxylation were identified, and plausible transformation pathways were proposed. The formation of transformation product species was found to be pH dependent due to the different oxidation abilities of delta-MnO2 under different pH conditions. The sulfoxide-type products formed in this study were previously reported to exhibit high genotoxicity. Therefore, the potential ecological risk of cefazolin transformation in natural sediments and soils is sufficient to merit concern. (C) 2017 Elsevier B.V. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39389]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Liping,Wei, Dongbin,Wei, Guohua,et al. Product identification and the mechanisms involved in the transformation of cefazolin by birnessite (delta-MnO2)[J]. CHEMICAL ENGINEERING JOURNAL,2017,320(0):116-123. |
| APA | Li, Liping,Wei, Dongbin,Wei, Guohua,&Du, Yuguo.(2017).Product identification and the mechanisms involved in the transformation of cefazolin by birnessite (delta-MnO2).CHEMICAL ENGINEERING JOURNAL,320(0),116-123. |
| MLA | Li, Liping,et al."Product identification and the mechanisms involved in the transformation of cefazolin by birnessite (delta-MnO2)".CHEMICAL ENGINEERING JOURNAL 320.0(2017):116-123. |
入库方式： OAI收割
来源：生态环境研究中心
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