Response a chronic effects of PBDE-47: Up-regulations of HSP60 and HSP70 expression in freshwater bivalve Anodonta woodiana
文献类型：期刊论文
| 作者 | Xia, Xichao; Xue, Shipeng; Wang, Xiying; Zhang, Qingyuan; Huang, Chuanfeng; Guo, Lianghong; Yao, Lunguang |
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2017-03-01 |
| 卷号 | 65期号:0页码:213-225 |
| 关键词 | Anodonta Woodiana Pbde-47 Awhsp60 Awhsp70 |
| 英文摘要 | Heat shock proteins (HSPs) play an important role in adaption of environmental stress by protein folding, membrane translocation, degradation of misfolded proteins and other regulatory processes. Our previous study showed oxidative stress generated from polybrominated diphenyl ether-47 (PBDE-47) could cause an acute toxicity on freshwater bivalve Anodonta Woodiana, but the effect of chronic toxicity need to be elucidated. In order to further investigate the chronic effect of PBDE-47, clams A. Woodiana were randomly divided into the PBDE-47 treated group administrated with PBDE-47 at a concentration 3.36 mu g/L and control group treated with a similar volume dimethyl sulfoxide. Two complete HSP sequences were isolated from A. Woodianaa and respectively named AwHSP60 and AwHSP70. They were widely distributed in foot, gill, hepatopancreas, adductor muscle, heart, hemocytes and mantle. Administration of PBDE-47 could result in a significant up-regulation of AwHSP60 and AwHSP70 expressions in the hepatopancreas, gill and hemocytes. In the hepatopancreas, compared with that of control group, mRNA level of AwHSP60 increased more than 89.9% (P < 0.05) from day 1-15, AwHSP70 increased more 2.79 times (P < 0.01). In the gill, during experiment observed, expression of AwHSP60 increased more 2.09 times (P < 0.01) in contrasted with that of control group. Significant up-regulation of AwHSP70 expression showed a reversed U shape. In the hemocytes, AwHSP60 and AwHSP70 expressions of PBDE-47 treated group respectively increased more 2.09 times (P < 0.05) and 1.81 times (P < 0.05) compared with that of control group. These results indicated that up-regulations of AwHSP60 and AwHSP70 expression are contribute to enhancing adaption of bivalve A. Woodiana exposed to PBDE-47 treatment. (C) 2017 Published by Elsevier Ltd. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39405]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Xia, Xichao,Xue, Shipeng,Wang, Xiying,et al. Response a chronic effects of PBDE-47: Up-regulations of HSP60 and HSP70 expression in freshwater bivalve Anodonta woodiana[J]. FISH & SHELLFISH IMMUNOLOGY,2017,65(0):213-225. |
| APA | Xia, Xichao.,Xue, Shipeng.,Wang, Xiying.,Zhang, Qingyuan.,Huang, Chuanfeng.,...&Yao, Lunguang.(2017).Response a chronic effects of PBDE-47: Up-regulations of HSP60 and HSP70 expression in freshwater bivalve Anodonta woodiana.FISH & SHELLFISH IMMUNOLOGY,65(0),213-225. |
| MLA | Xia, Xichao,et al."Response a chronic effects of PBDE-47: Up-regulations of HSP60 and HSP70 expression in freshwater bivalve Anodonta woodiana".FISH & SHELLFISH IMMUNOLOGY 65.0(2017):213-225. |
入库方式： OAI收割
来源：生态环境研究中心
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