Developmental toxicity and thyroid hormone-disrupting effects of 2,4-dichloro-6-nitrophenol in Chinese rare minnow (Gobiocypris rarus)
文献类型：期刊论文
| 作者 | Zha, Jinmiao; Chen, Rui; Yuan, Lilai; Wang, Zijian |
| 刊名 | AQUATIC TOXICOLOGY
 |
| 出版日期 | 2017-04-01 |
| 卷号 | 185期号:0页码:40-47 |
| 关键词 | Chinese Rare Minnow Thyroid Hormones 2 Hypothalamic-pituitary-thyroid Axis 4-dichloro-6-nitrophenol Endocrine Disruption |
| 英文摘要 | In the present study, to evaluate embryonic toxicity and the thyroid-disrupting effects of 2,4-dichloro-6nitrophenol (DCNP), embryos and adults of Chinese rare minnow (Gobiocypris rarus) were exposed to 2, 20, and 200 DCNP. In the embryo-larval assay, increased percentages of mortality and occurrence of malformations, decreased percentage of hatching, and decreased body length and body weight were observed after DCNP treatment. Moreover, the whole -body T3 levels were significantly increased at 20 and 200 mu g/L treatments, whereas the T4 levels were markedly decreased significantly (p <0.05) for all DCNP concentrations. In the adult fish assay, plasma T3 levels were significantly increased whereas plasma T4 levels were significantly reduced in the fish treated with 20 and 200 mu g/L(p < 0.05). In addition, DCNP exposure significantly changed the transcription levels of thyroid system related genes, including diol, dio2, me, nis, tr, and ttr. The increased responsiveness of thyroid hormone and mRNA expression levels of thyroid system related genes suggested that DCNP could disrupt the thyroid hormone synthesis and transport pathways. Therefore, our findings provide new insights of DCNP as a thyroid hormone disrupting chemical. (C) 2017 Elsevier B.V. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39491]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zha, Jinmiao,Chen, Rui,Yuan, Lilai,et al. Developmental toxicity and thyroid hormone-disrupting effects of 2,4-dichloro-6-nitrophenol in Chinese rare minnow (Gobiocypris rarus)[J]. AQUATIC TOXICOLOGY,2017,185(0):40-47. |
| APA | Zha, Jinmiao,Chen, Rui,Yuan, Lilai,&Wang, Zijian.(2017).Developmental toxicity and thyroid hormone-disrupting effects of 2,4-dichloro-6-nitrophenol in Chinese rare minnow (Gobiocypris rarus).AQUATIC TOXICOLOGY,185(0),40-47. |
| MLA | Zha, Jinmiao,et al."Developmental toxicity and thyroid hormone-disrupting effects of 2,4-dichloro-6-nitrophenol in Chinese rare minnow (Gobiocypris rarus)".AQUATIC TOXICOLOGY 185.0(2017):40-47. |
入库方式： OAI收割
来源：生态环境研究中心
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