Histopathological and proteomic responses in male Chinese rare minnow (Gobiocypris rarus) indicate hepatotoxicity following benzotriazole exposure
文献类型：期刊论文
| 作者 | Liang, Xuefang; Zha, Jinmiao; Martyniuk, Christopher J.; Wang, Zijian; Zhao, Ji |
| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2017-10-01 |
| 卷号 | 229期号:0页码:459-469 |
| 关键词 | Liver Proteome Histological Damage Oxidative Stress Benzotriazole Chinese Rare Minnow (Gobiocypris Rarus) |
| 英文摘要 | Benzotriazole (BT) and its associated derivatives are used ubiquitously in industrial processes, and can be detected in indoor temperature coolants and in chemicals designed to inhibit corrosion. This chemical has been widely detected in aquatic environments and shows some degree of environmental persistence. Evidence has shown that BT exposure can negatively affect endocrine systems and can result in neurotoxicity in fish. However, no study has examined whether this chemical exhibits hepatotoxicity in fish, and if so, what are the underlying mechanism associated with the damage. To address this knowledge gap, we measured the liver proteome of adult male Chinese rare minnow (Gobiocypris rams) exposed to either 0.05, 0.5, or 5 mg/L BT for 28 days. Overall, 17 proteins were induced and 9 were reduced in abundance following BT treatment (ratio > 1.5, p < 0.05). Pathway analysis revealed that cellular processes affected by BT included xenobiotic clearance, oxidative stress response, apoptosis, and translation. Moreover, transcripts related to these toxic pathways were also significantly affected by BT. In addition, rare minnows exposed to BT showed signs of hypertrophy of hepatocytes, nuclei pyknosis, and higher levels of cellular vacuolization compared to the controls, thus these early proteomic responses in the liver may be related to pathology (i.e. adverse outcome pathway). Our data demonstrate that BT dysregulates molecular responses in the liver and tissue pathology indicative of damage. This study provides new insight into BT hepatotoxicity in Chinese rare minnow. (C) 2017 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/39512]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Liang, Xuefang,Zha, Jinmiao,Martyniuk, Christopher J.,et al. Histopathological and proteomic responses in male Chinese rare minnow (Gobiocypris rarus) indicate hepatotoxicity following benzotriazole exposure[J]. ENVIRONMENTAL POLLUTION,2017,229(0):459-469. |
| APA | Liang, Xuefang,Zha, Jinmiao,Martyniuk, Christopher J.,Wang, Zijian,&Zhao, Ji.(2017).Histopathological and proteomic responses in male Chinese rare minnow (Gobiocypris rarus) indicate hepatotoxicity following benzotriazole exposure.ENVIRONMENTAL POLLUTION,229(0),459-469. |
| MLA | Liang, Xuefang,et al."Histopathological and proteomic responses in male Chinese rare minnow (Gobiocypris rarus) indicate hepatotoxicity following benzotriazole exposure".ENVIRONMENTAL POLLUTION 229.0(2017):459-469. |
入库方式： OAI收割
来源：生态环境研究中心
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