Highly efficient regio- and stereoselective synthesis of beta-(1 -> 6)-branched beta-(1 -> 3)-linked glucohexaose and its analogue
文献类型：期刊论文
| 作者 | Yi Yue-Tao; Zhao Qian-Fei; Qian Feng-Zhen; Ning Jun |
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2007-03 |
| 卷号 | 25期号:3页码:385-389 |
| 关键词 | Gluco-hexasaccharide Antitumor Activity Regio- And Stereoselective Synthesis |
| 英文摘要 | A beta-(1 -> 6)-branched beta-(1 -> 3)-linked glucohexaose (1) and its lauryl glycoside (2), present in many biologically active polysaccharides from traditional herbal medicines such as Ganoderma lucidum, Schizophyllum commune and Lentinus edodes, were highly efficiently synthesized. Coupling of 2,3,4,6-tetra-O-benzoyl-i-beta-glucopyranosyl(1 -> 3)-2-O-benzoyl-4,6-O-benzylidene-alpha-D-glucopyranosyl trichloroacetimidate (7) with 3,6-branched acceptors 8 and 12 gave beta-(1 -> 3)-linked pentasaccharides (9) and (13), then via simple chemical transformation 4',6'-OH pentasaccharide acceptors 10 and 14 were obtained. Regio- and stereoselective coupling of 3 with 10 and 14 gave beta-(1 -> 3)-linked hexasaccharides (11) and (15) as the major products. Deprotection of 11 and 15 provided the target sugar 1 and 2. Thus, a new method for the preparation of this kind of compounds was developed. |
| WOS记录号 | WOS:000244805800023 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/22668]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Yi Yue-Tao,Zhao Qian-Fei,Qian Feng-Zhen,et al. Highly efficient regio- and stereoselective synthesis of beta-(1 -> 6)-branched beta-(1 -> 3)-linked glucohexaose and its analogue[J]. CHINESE JOURNAL OF CHEMISTRY,2007,25(3):385-389. |
| APA | Yi Yue-Tao,Zhao Qian-Fei,Qian Feng-Zhen,&Ning Jun.(2007).Highly efficient regio- and stereoselective synthesis of beta-(1 -> 6)-branched beta-(1 -> 3)-linked glucohexaose and its analogue.CHINESE JOURNAL OF CHEMISTRY,25(3),385-389. |
| MLA | Yi Yue-Tao,et al."Highly efficient regio- and stereoselective synthesis of beta-(1 -> 6)-branched beta-(1 -> 3)-linked glucohexaose and its analogue".CHINESE JOURNAL OF CHEMISTRY 25.3(2007):385-389. |
入库方式： OAI收割
来源：生态环境研究中心
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