An efficient and concise synthesis of a beta-(1 -> 6)-linked D-galactofuranosyl hexasaccharide
文献类型：期刊论文
| 作者 | Zhang, GH; Fu, MK; Ning, J |
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2005 |
| 卷号 | 340期号:1页码:155-159 |
| 关键词 | Galactofuranosyl Hexasaccharide Trichloroacetimidate Synthesis |
| DOI | 10.1016/j.carres.2004.11.001 |
| 英文摘要 | A O-(1 --> 6)-linked D-galactofuranosyl hexasaccharide was synthesized efficiently in a block construction manner by the well-known Schmidt glycosylation method using 6-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-galactofuranosyl trichloroacetimidate (1) and allyl 2,3,5-tri-O-benzoyl-beta-D-galactofuranoside (3) as the key synthons. Coupling of 3 with I gave beta-(1 --> 6)-linked disaccharide 4. Subsequent selective deacetylation of 4 afforded the disaccharide acceptor 5, while deallylation of 4 followed by trichloroacetimidate formation produced the disaccharide donor 6. Condensation of 5 with 6 gave the tetrasaccharide 7, and subsequent deacetylation afforded the tetrasaccharide acceptor 8. Finally, coupling of 8 with 6 followed by deacylation yielded the target beta-(1 --> 6)-linked galactofuranose hexasaccharide 10. All of the reactions in the synthesis were carried out smoothly and in high yield. (C) 2004 Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000226538800019 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/23361]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, GH,Fu, MK,Ning, J. An efficient and concise synthesis of a beta-(1 -> 6)-linked D-galactofuranosyl hexasaccharide[J]. CARBOHYDRATE RESEARCH,2005,340(1):155-159. |
| APA | Zhang, GH,Fu, MK,&Ning, J.(2005).An efficient and concise synthesis of a beta-(1 -> 6)-linked D-galactofuranosyl hexasaccharide.CARBOHYDRATE RESEARCH,340(1),155-159. |
| MLA | Zhang, GH,et al."An efficient and concise synthesis of a beta-(1 -> 6)-linked D-galactofuranosyl hexasaccharide".CARBOHYDRATE RESEARCH 340.1(2005):155-159. |
入库方式： OAI收割
来源：生态环境研究中心
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