First synthesis of the immunodominant beta-galactofuranose-containing tetrasaccharide present in the cell wall of Aspergillus fumigatus
文献类型：期刊论文
| 作者 | Fu, MK; Zhang, GH; Ning, J |
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2005 |
| 卷号 | 340期号:1页码:25-30 |
| 关键词 | Oligosaccharide Galactofuranose Synthesis |
| DOI | 10.1016/j.carres.2004.10.019 |
| 英文摘要 | beta-Galf-(1 --> 5)-p-Galf-(1 --> 6)-alpha-Manp-(1 --> 6)-alpha-Manp, the immunodominant epitope in the cell-wall galactomannan of Aspergillus fumigatus, was synthesized for the first time as its allyl glycoside. The key disaccharide glycosyl donor, 2,3,5,6-tetra- O-benzoyl-beta-D-galactofuranosyl-(1 --> 5)-2-O-acetyl- 3,6-di-O-benzoyl-beta-D -galactofuranosyl trichloroacetimidate (10), was constructed by 5-O-glycosylation of 1,2-O-isopropylidene-3,6-di-O-benzoyl-alpha-D-galactofuranose (4) with 2,3,5,6-tetra-O-benzoyl-beta-galactofuranosyl trichloroacetimidate (5), followed by 1,2-O-deacetonation, acetylation, selective 1-O-deacetylation, and trichloroacetimidation. The target tetrasaccharide 16 was obtained by the condensation of allyl 2,3,4-tri-O-benzoyl-alpha-D-mannopyranosyl-(1 --> 6)-2,3,4-tri-O-benzoyl-alpha-D-mannopyranoside (14) as glycosyl acceptor with the disaccharide glycosyl donor 10, followed by deprotection. (C) 2004 Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Chemistry |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000226538800003 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/23369]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Fu, MK,Zhang, GH,Ning, J. First synthesis of the immunodominant beta-galactofuranose-containing tetrasaccharide present in the cell wall of Aspergillus fumigatus[J]. CARBOHYDRATE RESEARCH,2005,340(1):25-30. |
| APA | Fu, MK,Zhang, GH,&Ning, J.(2005).First synthesis of the immunodominant beta-galactofuranose-containing tetrasaccharide present in the cell wall of Aspergillus fumigatus.CARBOHYDRATE RESEARCH,340(1),25-30. |
| MLA | Fu, MK,et al."First synthesis of the immunodominant beta-galactofuranose-containing tetrasaccharide present in the cell wall of Aspergillus fumigatus".CARBOHYDRATE RESEARCH 340.1(2005):25-30. |
入库方式： OAI收割
来源：生态环境研究中心
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