A new and efficient strategy for the synthesis of shimofuridin analogs: 2 '-O-(4-O-stearoyl-alpha-L-fucopyranosyl)thymidine and -uridine
文献类型：期刊论文
| 作者 | Ning, J; Xing, Y; Kong, FZ |
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2003 |
| 卷号 | 338期号:1页码:55-60 |
| 关键词 | Oligosaccharides Nucleoside Synthesis |
| DOI | 10.1016/S0008-6215(02)00356-7 |
| 英文摘要 | Two shimofuridin analogs: 2'-O-(4-O-stearoyl-alpha-L-fucopyranosyl)thymidine (2) and -uridine (3) have been synthesized using D-arabinose, L-fucose, thymine, uracil, and stearoyl chloride as the starting materials. The synthetic procedures involve the facile preparation of 1-(3,5-di-O-benzyl-beta-D-ribofuranosyl)thymine (9) and -uracil (10) by coupling of 1,2-anhydro-3,5-di-O-benzyl-alpha-D-ribofuranose (8) with silylated thymine and uracil, and then stereoselective formation of the 1,2-cis (alpha) interglycoside bonds through condensation of the nucleoside derivatives 9 and 10 with 2-(2,3-di-O-benzyl-4-O-stearoyl-beta-L-fucopyranosylsulfonyl) pyrimidine (18). The 1,2-anhydro-3,5-di-O-benzyl-alpha-D-ribofuranose (8) was prepared by an improved procedure from D-arabinose. (C) 2002 Elsevier Science Ltd. All rights reserved. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000180405000007 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/23809]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Ning, J,Xing, Y,Kong, FZ. A new and efficient strategy for the synthesis of shimofuridin analogs: 2 '-O-(4-O-stearoyl-alpha-L-fucopyranosyl)thymidine and -uridine[J]. CARBOHYDRATE RESEARCH,2003,338(1):55-60. |
| APA | Ning, J,Xing, Y,&Kong, FZ.(2003).A new and efficient strategy for the synthesis of shimofuridin analogs: 2 '-O-(4-O-stearoyl-alpha-L-fucopyranosyl)thymidine and -uridine.CARBOHYDRATE RESEARCH,338(1),55-60. |
| MLA | Ning, J,et al."A new and efficient strategy for the synthesis of shimofuridin analogs: 2 '-O-(4-O-stearoyl-alpha-L-fucopyranosyl)thymidine and -uridine".CARBOHYDRATE RESEARCH 338.1(2003):55-60. |
入库方式： OAI收割
来源：生态环境研究中心
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