A facile large scale synthesis of the core mannose pentasaccharide of N-linked glycoprotein and its isomer
文献类型：期刊论文
| 作者 | Zhang, JJ; Kong, FZ |
| 刊名 | ACTA CHIMICA SINICA
 |
| 出版日期 | 2002 |
| 卷号 | 60期号:1页码:150-156 |
| 关键词 | Mannose Oligosaccharides Regio- And Stereoselective Synthesis |
| 英文摘要 | Condensation with 1,2-O-ethylidene-4,6-O-benzylidene-beta-D-mannopyranose (2) as the acceptor wand 2,3,4,6-tetra-O-benzoyl-alpha-D-mannopyranosyl trichloroacetimidate (3) as the donor gave 3-O-linked disaccharide (4), subsequent debenzylidenation afforded the disaccharide acceptor 5. Coupling of 5 with 3 selectively furnished 6-O-linked trisaccharide 6, then deethylidenation, acetylation, selective 1-O-deacetylation, and trichloroacetimidation yielded the trisaccharide donor 10. Condensation of 10 with 5 afforded 6-O-linked pentasaccharide 11, its deethylidenation followed by acetylation gave the required pentasaccharide 13. Coupling of 10 with 2 gave the tetrasaccharide 14, its debenzylidenation afforded the tetrasaccharide acceptor 15. Condensation of 15 with 3 gave the pentasaccharide isomer. |
| WOS研究方向 | Chemistry |
| WOS记录号 | WOS:000173368700027 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/23957]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, JJ,Kong, FZ. A facile large scale synthesis of the core mannose pentasaccharide of N-linked glycoprotein and its isomer[J]. ACTA CHIMICA SINICA,2002,60(1):150-156. |
| APA | Zhang, JJ,&Kong, FZ.(2002).A facile large scale synthesis of the core mannose pentasaccharide of N-linked glycoprotein and its isomer.ACTA CHIMICA SINICA,60(1),150-156. |
| MLA | Zhang, JJ,et al."A facile large scale synthesis of the core mannose pentasaccharide of N-linked glycoprotein and its isomer".ACTA CHIMICA SINICA 60.1(2002):150-156. |
入库方式： OAI收割
来源：生态环境研究中心
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